Intrinsic unstructuredness and abundance of PEST motifs in eukaryotic proteomes

• Published in: Proteins, structure, function, and bioinformatics Vol. 62; no. 2; pp. 309 - 315
• Main Authors: Singh, Gajinder Pal, Ganapathi, Mythily, Sandhu, Kuljeet Singh, Dash, Debasis
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2006
• Subjects: Amino Acid Sequence; Animals; Genome; Humans; PEST motifs; protein degradation signals; Protein Denaturation; protein disorder; Protein Folding; protein unfoldedness; Proteins - chemistry; Proteins - genetics; proteolysis; Proteome; Surface Properties; unstructured regions

The study of unfolded protein regions has gained importance because of their prevalence and important roles in various cellular functions. These regions have characteristically high net charge and low hydrophobicity. The amino acid sequence determines the intrinsic unstructuredness of a region and,...