Safety, tolerability, pharmacokinetics, and effects on human experimental pain of the selective ionotropic glutamate receptor 5 (iGluR5) antagonist LY545694 in healthy volunteers - Petersen, Karin L.; Iyengar, Smriti; Chappell, Amy S.; Lobo, Evelyn D.; Reda, Haatem; Prucka, William R.; Verfaille, Steven J. (Pain (Amsterdam), 2014)
Keywords: Adult; Analgesic; Analgesics; Antihyperalgesic; Biological and medical sciences; Brief thermal stimulation model; Cross-Over Studies; Double-Blind Method; Efficacy; Excitatory Amino Acid Antagonists - adverse effects; Excitatory Amino Acid Antagonists - pharmacokinetics; Excitatory Amino Acid Antagonists - therapeutic use; Female; Healthy Volunteers; Human experimental pain model; Humans; Hyperalgesia; Ionotropic glutamate receptor 5 receptor antagonist; Isoquinolines - adverse effects; Isoquinolines - pharmacokinetics; Isoquinolines - therapeutic use; Male; Medical sciences; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurology; Neuropharmacology; Pain - drug therapy; Pharmacology. Drug treatments; Prodrugs - adverse effects; Prodrugs - pharmacokinetics; Prodrugs - therapeutic use; Tetrazoles - adverse effects; Tetrazoles - pharmacokinetics; Tetrazoles - therapeutic use; Treatment Outcome; Young Adult; Antihyperalgesic; Analgesic; Human experimental pain model; Brief thermal stimulation model; Efficacy; Ionotropic glutamate receptor 5 receptor antagonist; Hyperalgesia; Human; Ionotropic receptor; Nervous system diseases; Healthy subject; Stimulation; Glutamate receptor; Pain; Models; Antagonist; Safety; Pharmacokinetics; Biological receptor