Experimental infection with Ehrlichia phagocytophila in cattle

Summary Twenty Norwegian Red cattle, aged 8–10 months were used. Ten animals were inoculated intravenously with 3 ml of a whole blood dimethyl sulphoxide stabilate of a bovine strain of Ehrlichia (Cytoecetes) phagocytophila. The animals were observed on a daily basis for clinical symptoms and rectal...

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Published inJournal of veterinary medicine. Series B Vol. 45; no. 4; pp. 193 - 203
Main Authors Brun-Hansen, H, Gronstol, H, Hardeng, F
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.05.1998
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Abstract Summary Twenty Norwegian Red cattle, aged 8–10 months were used. Ten animals were inoculated intravenously with 3 ml of a whole blood dimethyl sulphoxide stabilate of a bovine strain of Ehrlichia (Cytoecetes) phagocytophila. The animals were observed on a daily basis for clinical symptoms and rectal temperatures were recorded daily for 36 days post inoculation. Blood and serum samples were collected regularly during the observation period. All infected animals developed fever of 2–4 days duration within a week. Six out of 10 animals had secondary temperature rises of 1–2 days duration. Three animals showed swellings in the hind limbs and a stiff gait. Compared with the control group, there was a 10% decrease in the mean haematocrit and a leukopenia that initially was due to a lymphopenia and later to a neutropenia. A monocytosis occurred after the subsidence of the primary fever period. A thrombocytopenia occurred during the early phase of infection. Granulocytic inclusions were detected for 18–32 days. All infected animals developed antibodies ≥ 1: 4096 to E. phagocytophila within 14 days post infection.
AbstractList Summary Twenty Norwegian Red cattle, aged 8–10 months were used. Ten animals were inoculated intravenously with 3 ml of a whole blood dimethyl sulphoxide stabilate of a bovine strain of Ehrlichia (Cytoecetes) phagocytophila. The animals were observed on a daily basis for clinical symptoms and rectal temperatures were recorded daily for 36 days post inoculation. Blood and serum samples were collected regularly during the observation period. All infected animals developed fever of 2–4 days duration within a week. Six out of 10 animals had secondary temperature rises of 1–2 days duration. Three animals showed swellings in the hind limbs and a stiff gait. Compared with the control group, there was a 10% decrease in the mean haematocrit and a leukopenia that initially was due to a lymphopenia and later to a neutropenia. A monocytosis occurred after the subsidence of the primary fever period. A thrombocytopenia occurred during the early phase of infection. Granulocytic inclusions were detected for 18–32 days. All infected animals developed antibodies ≥ 1: 4096 to E. phagocytophila within 14 days post infection.
Twenty Norwegian Red cattle, aged 8-10 months were used. Ten animals were inoculated intravenously with 3 ml of a whole blood dimethyl sulphoxide stabilate of a bovine strain of Ehrlichia (Cytoecetes) phagocytophila. The animals were observed on a daily basis for clinical symptoms and rectal temperatures were recorded daily for 36 days post inoculation. Blood and serum samples were collected regularly during the observation period. All infected animals developed fever of 2-4 days duration within a week. Six out of 10 animals had secondary temperature rises of 1-2 days duration. Three animals showed swellings in the hind limbs and a stiff gait. Compared with the control group, there was a 10% decrease in the mean haematocrit and a leukopenia that initially was due to a lymphopenia and later to a neutropenia. A monocytosis occurred after the subsidence of the primary fever period. A thrombocytopenia occurred during the early phase of infection. Granulocytic inclusions were detected for 18-32 days. All infected animals developed antibodies > or = 1:4096 to E. phagocytophila within 14 days post infection.
Summary Twenty Norwegian Red cattle, aged 8–10 months were used. Ten animals were inoculated intravenously with 3 ml of a whole blood dimethyl sulphoxide stabilate of a bovine strain of Ehrlichia (Cytoecetes) phagocytophila. The animals were observed on a daily basis for clinical symptoms and rectal temperatures were recorded daily for 36 days post inoculation. Blood and serum samples were collected regularly during the observation period. All infected animals developed fever of 2–4 days duration within a week. Six out of 10 animals had secondary temperature rises of 1–2 days duration. Three animals showed swellings in the hind limbs and a stiff gait. Compared with the control group, there was a 10% decrease in the mean haematocrit and a leukopenia that initially was due to a lymphopenia and later to a neutropenia. A monocytosis occurred after the subsidence of the primary fever period. A thrombocytopenia occurred during the early phase of infection. Granulocytic inclusions were detected for 18–32 days. All infected animals developed antibodies ≥ 1: 4096 to E. phagocytophila within 14 days post infection.
Author Gronstol, H
Hardeng, F
Brun-Hansen, H
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1994; 111
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1989; 21
1982; 92
1965; 121
1991; 32
1962; 6
1967c; 71
1991; 51
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1993
1977; 100
1992; 33
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1987; 190
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1992; 52
1980; 136
1991; 29
1990; 42
1968; 78
1984; 96
1993; 34
1989; 34
1984; 16
1988; 49
1956; 66
1967a; 70
1994; 56
1932; 45
1950; 106
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1966; 44
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1983; 44
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Stuen S. (e_1_2_1_29_1) 1995
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ØVerås J. (e_1_2_1_24_1) 1962; 14
Tuomi J. (e_1_2_1_32_1) 1966; 44
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Snippet Summary Twenty Norwegian Red cattle, aged 8–10 months were used. Ten animals were inoculated intravenously with 3 ml of a whole blood dimethyl sulphoxide...
Twenty Norwegian Red cattle, aged 8-10 months were used. Ten animals were inoculated intravenously with 3 ml of a whole blood dimethyl sulphoxide stabilate of...
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SubjectTerms Anaplasma phagocytophilum
Animals
Antibodies, Bacterial - biosynthesis
Antibodies, Bacterial - blood
basophils
Blood Cell Count - veterinary
Body Temperature
Cattle
Cattle Diseases - blood
Cattle Diseases - immunology
Cattle Diseases - physiopathology
clinical aspects
Ehrlichia - immunology
Ehrlichiosis - blood
Ehrlichiosis - immunology
Ehrlichiosis - veterinary
eosinophils
experimental infections
Female
Gait
hematocrit
hemoglobin
immune response
immunology
leukocyte count
leukopenia
lymphocytes
Male
monocytes
monocytosis
neutrophils
symptoms
thrombocytopenia
Title Experimental infection with Ehrlichia phagocytophila in cattle
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https://www.ncbi.nlm.nih.gov/pubmed/9640099
Volume 45
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