Experimental infection with Ehrlichia phagocytophila in cattle
Summary Twenty Norwegian Red cattle, aged 8–10 months were used. Ten animals were inoculated intravenously with 3 ml of a whole blood dimethyl sulphoxide stabilate of a bovine strain of Ehrlichia (Cytoecetes) phagocytophila. The animals were observed on a daily basis for clinical symptoms and rectal...
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| Published in | Journal of veterinary medicine. Series B Vol. 45; no. 4; pp. 193 - 203 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.05.1998
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Summary
Twenty Norwegian Red cattle, aged 8–10 months were used. Ten animals were inoculated intravenously with 3 ml of a whole blood dimethyl sulphoxide stabilate of a bovine strain of Ehrlichia (Cytoecetes) phagocytophila. The animals were observed on a daily basis for clinical symptoms and rectal temperatures were recorded daily for 36 days post inoculation. Blood and serum samples were collected regularly during the observation period. All infected animals developed fever of 2–4 days duration within a week. Six out of 10 animals had secondary temperature rises of 1–2 days duration. Three animals showed swellings in the hind limbs and a stiff gait. Compared with the control group, there was a 10% decrease in the mean haematocrit and a leukopenia that initially was due to a lymphopenia and later to a neutropenia. A monocytosis occurred after the subsidence of the primary fever period. A thrombocytopenia occurred during the early phase of infection. Granulocytic inclusions were detected for 18–32 days. All infected animals developed antibodies ≥ 1: 4096 to E. phagocytophila within 14 days post infection. |
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| AbstractList | Summary
Twenty Norwegian Red cattle, aged 8–10 months were used. Ten animals were inoculated intravenously with 3 ml of a whole blood dimethyl sulphoxide stabilate of a bovine strain of
Ehrlichia (Cytoecetes) phagocytophila.
The animals were observed on a daily basis for clinical symptoms and rectal temperatures were recorded daily for 36 days post inoculation. Blood and serum samples were collected regularly during the observation period. All infected animals developed fever of 2–4 days duration within a week. Six out of 10 animals had secondary temperature rises of 1–2 days duration. Three animals showed swellings in the hind limbs and a stiff gait. Compared with the control group, there was a 10% decrease in the mean haematocrit and a leukopenia that initially was due to a lymphopenia and later to a neutropenia. A monocytosis occurred after the subsidence of the primary fever period. A thrombocytopenia occurred during the early phase of infection. Granulocytic inclusions were detected for 18–32 days. All infected animals developed antibodies ≥ 1: 4096 to
E. phagocytophila
within 14 days post infection. Twenty Norwegian Red cattle, aged 8-10 months were used. Ten animals were inoculated intravenously with 3 ml of a whole blood dimethyl sulphoxide stabilate of a bovine strain of Ehrlichia (Cytoecetes) phagocytophila. The animals were observed on a daily basis for clinical symptoms and rectal temperatures were recorded daily for 36 days post inoculation. Blood and serum samples were collected regularly during the observation period. All infected animals developed fever of 2-4 days duration within a week. Six out of 10 animals had secondary temperature rises of 1-2 days duration. Three animals showed swellings in the hind limbs and a stiff gait. Compared with the control group, there was a 10% decrease in the mean haematocrit and a leukopenia that initially was due to a lymphopenia and later to a neutropenia. A monocytosis occurred after the subsidence of the primary fever period. A thrombocytopenia occurred during the early phase of infection. Granulocytic inclusions were detected for 18-32 days. All infected animals developed antibodies > or = 1:4096 to E. phagocytophila within 14 days post infection. Summary Twenty Norwegian Red cattle, aged 8–10 months were used. Ten animals were inoculated intravenously with 3 ml of a whole blood dimethyl sulphoxide stabilate of a bovine strain of Ehrlichia (Cytoecetes) phagocytophila. The animals were observed on a daily basis for clinical symptoms and rectal temperatures were recorded daily for 36 days post inoculation. Blood and serum samples were collected regularly during the observation period. All infected animals developed fever of 2–4 days duration within a week. Six out of 10 animals had secondary temperature rises of 1–2 days duration. Three animals showed swellings in the hind limbs and a stiff gait. Compared with the control group, there was a 10% decrease in the mean haematocrit and a leukopenia that initially was due to a lymphopenia and later to a neutropenia. A monocytosis occurred after the subsidence of the primary fever period. A thrombocytopenia occurred during the early phase of infection. Granulocytic inclusions were detected for 18–32 days. All infected animals developed antibodies ≥ 1: 4096 to E. phagocytophila within 14 days post infection. |
| Author | Gronstol, H Hardeng, F Brun-Hansen, H |
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| CitedBy_id | crossref_primary_10_1016_j_vetpar_2009_09_013 crossref_primary_10_1556_avet_56_2008_3_2 crossref_primary_10_3390_life13020469 crossref_primary_10_1196_annals_1374_084 |
| Cites_doi | 10.1016/S0007-1935(17)32239-X 10.1016/S0368-1742(32)80025-1 10.1016/0378-1135(89)90025-4 10.1016/S0007-1935(17)53027-4 10.1136/vr.110.7.151 10.1016/S0007-1935(17)41151-1 10.1016/0034-5288(92)90012-Q 10.1016/0034-5288(91)90028-M 10.1111/j.1699-0463.1967.tb01327.x 10.1016/S0021-9975(08)80255-1 10.1016/0304-4017(84)90040-2 10.1016/0021-9975(87)90075-2 10.1128/JCM.29.12.2838-2842.1991 10.1016/S0368-1742(56)80029-5 10.1136/vr.118.15.415 10.1186/BF03546950 10.1136/vr.100.1.4 10.1016/S0021-9975(05)80009-X 10.1016/0034-5288(94)90107-4 10.1111/j.1699-0463.1967.tb05147.x 10.1111/j.1699-0463.1967.tb01311.x 10.1186/BF03548222 10.1016/0021-9975(68)90102-3 10.1016/0021-9975(82)90026-3 10.1016/0304-4017(89)90172-6 |
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Twenty Norwegian Red cattle, aged 8–10 months were used. Ten animals were inoculated intravenously with 3 ml of a whole blood dimethyl sulphoxide... Twenty Norwegian Red cattle, aged 8-10 months were used. Ten animals were inoculated intravenously with 3 ml of a whole blood dimethyl sulphoxide stabilate of... |
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| SubjectTerms | Anaplasma phagocytophilum Animals Antibodies, Bacterial - biosynthesis Antibodies, Bacterial - blood basophils Blood Cell Count - veterinary Body Temperature Cattle Cattle Diseases - blood Cattle Diseases - immunology Cattle Diseases - physiopathology clinical aspects Ehrlichia - immunology Ehrlichiosis - blood Ehrlichiosis - immunology Ehrlichiosis - veterinary eosinophils experimental infections Female Gait hematocrit hemoglobin immune response immunology leukocyte count leukopenia lymphocytes Male monocytes monocytosis neutrophils symptoms thrombocytopenia |
| Title | Experimental infection with Ehrlichia phagocytophila in cattle |
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