Magnetic resonance imaging and spectroscopy for monitoring liver steatosis
Purpose To compare noninvasive MRI and magnetic resonance spectroscopy (MRS) methods with liver biopsy to quantify liver fat content. Materials and Methods Quantification of liver fat was compared by liver biopsy, proton MRS, and MRI using in‐phase/out‐of‐phase (IP/OP) and plus/minus fat saturation...
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| Published in | Journal of magnetic resonance imaging Vol. 28; no. 4; pp. 937 - 945 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.10.2008
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Purpose
To compare noninvasive MRI and magnetic resonance spectroscopy (MRS) methods with liver biopsy to quantify liver fat content.
Materials and Methods
Quantification of liver fat was compared by liver biopsy, proton MRS, and MRI using in‐phase/out‐of‐phase (IP/OP) and plus/minus fat saturation (±FS) techniques. The reproducibility of each MR measure was also determined. An additional group of overweight patients with steatosis underwent hepatic MRI and MRS before and after a six‐month weight‐loss program.
Results
A close correlation was demonstrated between histological assessment of steatosis and measurement of intrahepatocellular lipid (IHCL) by MRS (rs = 0.928, P < 0.0001) and MRI (IP/OP rs = 0.942, P < 0.0001; FS rs = 0.935, P < 0.0001). Following weight reduction, four of five patients with >5% weight loss had a decrease in IHCL of ≥50%.
Conclusion
These findings suggest that standard MRI protocols provide a rapid, safe, and quantitative assessment of hepatic steatosis. This is important because MRS is not available on all clinical MRI systems. This will enable noninvasive monitoring of the effects of interventions such as weight loss or pharmacotherapy in patients with fatty liver diseases. J. Magn. Reson. Imaging 2008;28:937–945. © 2008 Wiley‐Liss, Inc. |
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| AbstractList | To compare noninvasive MRI and magnetic resonance spectroscopy (MRS) methods with liver biopsy to quantify liver fat content.
Quantification of liver fat was compared by liver biopsy, proton MRS, and MRI using in-phase/out-of-phase (IP/OP) and plus/minus fat saturation (+/-FS) techniques. The reproducibility of each MR measure was also determined. An additional group of overweight patients with steatosis underwent hepatic MRI and MRS before and after a six-month weight-loss program.
A close correlation was demonstrated between histological assessment of steatosis and measurement of intrahepatocellular lipid (IHCL) by MRS (r(s) = 0.928, P < 0.0001) and MRI (IP/OP r(s) = 0.942, P < 0.0001; FS r(s) = 0.935, P < 0.0001). Following weight reduction, four of five patients with >5% weight loss had a decrease in IHCL of >or=50%.
These findings suggest that standard MRI protocols provide a rapid, safe, and quantitative assessment of hepatic steatosis. This is important because MRS is not available on all clinical MRI systems. This will enable noninvasive monitoring of the effects of interventions such as weight loss or pharmacotherapy in patients with fatty liver diseases. PURPOSETo compare noninvasive MRI and magnetic resonance spectroscopy (MRS) methods with liver biopsy to quantify liver fat content.MATERIALS AND METHODSQuantification of liver fat was compared by liver biopsy, proton MRS, and MRI using in-phase/out-of-phase (IP/OP) and plus/minus fat saturation (+/-FS) techniques. The reproducibility of each MR measure was also determined. An additional group of overweight patients with steatosis underwent hepatic MRI and MRS before and after a six-month weight-loss program.RESULTSA close correlation was demonstrated between histological assessment of steatosis and measurement of intrahepatocellular lipid (IHCL) by MRS (r(s) = 0.928, P < 0.0001) and MRI (IP/OP r(s) = 0.942, P < 0.0001; FS r(s) = 0.935, P < 0.0001). Following weight reduction, four of five patients with >5% weight loss had a decrease in IHCL of >or=50%.CONCLUSIONThese findings suggest that standard MRI protocols provide a rapid, safe, and quantitative assessment of hepatic steatosis. This is important because MRS is not available on all clinical MRI systems. This will enable noninvasive monitoring of the effects of interventions such as weight loss or pharmacotherapy in patients with fatty liver diseases. Purpose To compare noninvasive MRI and magnetic resonance spectroscopy (MRS) methods with liver biopsy to quantify liver fat content. Materials and Methods Quantification of liver fat was compared by liver biopsy, proton MRS, and MRI using in‐phase/out‐of‐phase (IP/OP) and plus/minus fat saturation (±FS) techniques. The reproducibility of each MR measure was also determined. An additional group of overweight patients with steatosis underwent hepatic MRI and MRS before and after a six‐month weight‐loss program. Results A close correlation was demonstrated between histological assessment of steatosis and measurement of intrahepatocellular lipid (IHCL) by MRS (rs = 0.928, P < 0.0001) and MRI (IP/OP rs = 0.942, P < 0.0001; FS rs = 0.935, P < 0.0001). Following weight reduction, four of five patients with >5% weight loss had a decrease in IHCL of ≥50%. Conclusion These findings suggest that standard MRI protocols provide a rapid, safe, and quantitative assessment of hepatic steatosis. This is important because MRS is not available on all clinical MRI systems. This will enable noninvasive monitoring of the effects of interventions such as weight loss or pharmacotherapy in patients with fatty liver diseases. J. Magn. Reson. Imaging 2008;28:937–945. © 2008 Wiley‐Liss, Inc. |
| Author | Powell, Elizabeth E. Jonsson, Julie R. Osland, Emma J. Purdie, David M. Galloway, Graham J. Ash, Susan Bauer, Judith D. Cowin, Gary J. Ali, Azmat Clouston, Andrew D. |
| Author_xml | – sequence: 1 givenname: Gary J. surname: Cowin fullname: Cowin, Gary J. email: gary.cowin@cmr.uq.edu.au organization: Centre for Magnetic Resonance, University of Queensland, Queensland, Australia – sequence: 2 givenname: Julie R. surname: Jonsson fullname: Jonsson, Julie R. organization: School of Medicine, Southern Division, University of Queensland, Queensland, Australia – sequence: 3 givenname: Judith D. surname: Bauer fullname: Bauer, Judith D. organization: Wesley Research Institute, Queensland, Australia – sequence: 4 givenname: Susan surname: Ash fullname: Ash, Susan organization: School of Public Health, Queensland University of Technology, Queensland, Australia – sequence: 5 givenname: Azmat surname: Ali fullname: Ali, Azmat organization: Department of Nutrition Services, Princess Alexandra Hospital, Queensland, Australia – sequence: 6 givenname: Emma J. surname: Osland fullname: Osland, Emma J. organization: Department of Nutrition Services, Princess Alexandra Hospital, Queensland, Australia – sequence: 7 givenname: David M. surname: Purdie fullname: Purdie, David M. organization: Genentech Inc., South San Francisco, California, USA – sequence: 8 givenname: Andrew D. surname: Clouston fullname: Clouston, Andrew D. organization: School of Medicine, Southern Division, University of Queensland, Queensland, Australia – sequence: 9 givenname: Elizabeth E. surname: Powell fullname: Powell, Elizabeth E. organization: School of Medicine, Southern Division, University of Queensland, Queensland, Australia – sequence: 10 givenname: Graham J. surname: Galloway fullname: Galloway, Graham J. organization: Centre for Magnetic Resonance, University of Queensland, Queensland, Australia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18821619$$D View this record in MEDLINE/PubMed |
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| Snippet | Purpose
To compare noninvasive MRI and magnetic resonance spectroscopy (MRS) methods with liver biopsy to quantify liver fat content.
Materials and Methods... To compare noninvasive MRI and magnetic resonance spectroscopy (MRS) methods with liver biopsy to quantify liver fat content. Quantification of liver fat was... PURPOSETo compare noninvasive MRI and magnetic resonance spectroscopy (MRS) methods with liver biopsy to quantify liver fat content.MATERIALS AND... |
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| SubjectTerms | Adipose Tissue - pathology Adult Biopsy Fatty Liver - etiology Fatty Liver - metabolism Fatty Liver - pathology fatty liver disease Female Humans Insulin Resistance liver fat Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy - methods Male Middle Aged obesity Obesity - complications Obesity - metabolism Obesity - pathology Reproducibility of Results Statistics, Nonparametric Triglycerides - metabolism weight loss |
| Title | Magnetic resonance imaging and spectroscopy for monitoring liver steatosis |
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