Inhibition of c-Kit signaling is associated with reduced heat and cold pain sensitivity in humans - Ceko, Marta; Milenkovic, Nevena; le Coutre, Philipp; Westermann, Jörg; Lewin, Gary R. (Pain (Amsterdam), 2014)
Keywords: Adult; Aged; Analgesia; Antineoplastic Agents - pharmacology; Benzamides - pharmacology; Biological and medical sciences; c-Kit; Case-Control Studies; Chronic myeloid leukemia; Cold pain; Cold Temperature; Female; Fundamental and applied biological sciences. Psychology; Heat pain; Hematologic and hematopoietic diseases; Hot Temperature; Humans; Imatinib; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Middle Aged; Nilotinib; Nociception - drug effects; Nociception - physiology; Pain - metabolism; Pain Perception - drug effects; Pain Perception - physiology; Pain Threshold; Piperazines - pharmacology; Proto-Oncogene Proteins c-kit - antagonists & inhibitors; Proto-Oncogene Proteins c-kit - metabolism; Pyrimidines - pharmacology; Quantitative sensory testing; Signal Transduction; Skin - drug effects; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Tactile acuity; Vertebrates: nervous system and sense organs; Nilotinib; Analgesia; Imatinib; c-Kit; Cold pain; Chronic myeloid leukemia; Tactile acuity; Heat pain; Quantitative sensory testing; Human; Pain sensitivity; Temperature; Cold; Leukemia; Environmental factor; Malignant hemopathy; Tactile sensitivity; Signal transduction; Heat; Chronic; Pain; Perception; Inhibition; Cancer