Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons

• Published in: Current biology Vol. 28; no. 11; pp. 1768 - 1782.e4
• Main Authors: Mire, Erik, Hocine, Mélanie, Bazellières, Elsa, Jungas, Thomas, Davy, Alice, Chauvet, Sophie, Mann, Fanny
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 04.06.2018; Elsevier
• Subjects: axon guidance; corpus callosum; cortex; ephrins; Life Sciences; neuropilins; semaphorins; cortex; neuropilins; ephrins; semaphorins; corpus callosum; axon guidance

The corpus callosum is the largest commissure in the brain, whose main function is to ensure communication between homotopic regions of the cerebral cortex. During fetal development, corpus callosum axons (CCAs) grow toward and across the brain midline and then away on the contralateral hemisphere t...