Urinary total conjugated 3-bromotyrosine, asthma severity, and exacerbation risk

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 323; no. 5; pp. L548 - L557
• Main Authors: Wang, Zeneng, Xu, Weiling, Comhair, Suzy A. A., Fu, Xiaoming, Shao, Zhili, Bearden, Rebecca, Zein, Joe G., Bleecker, Eugene R., Castro, Mario, Denlinger, Loren C., Fahy, John V., Israel, Elliot, Levy, Bruce D., Jarjour, Nizar N., Moore, Wendy C., Wenzel, Sally E., Mauger, David T., Gaston, Benjamin, Hazen, Stanley L., Erzurum, Serpil C.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.11.2022
• Series: Lung Diseases in Reverse Translation: Bedside to the Bench
• Subjects: Asthma; Asthma - diagnosis; Asthma - metabolism; Blood; Bromination; Eosinophil Peroxidase - metabolism; Eosinophils; Eosinophils - metabolism; Glucuronidase - metabolism; Health risks; Humans; Inflammatory diseases; Leukocyte Count; Leukocytes (eosinophilic); Liquid chromatography; Mass spectrometry; Mass spectroscopy; Methanesulfonic acid; Oxidation; Peroxidase; Sputum; Sputum - metabolism; Urine; 3-bromotyrosine; asthma; eosinophil; exacerbation

Asthma is an inflammatory disease of the airways characterized by eosinophil recruitment, eosinophil peroxidase release, and protein oxidation through bromination, which following tissue remodeling results in excretion of 3-bromotyrosine. Predicting exacerbations and reducing their frequency is crit...