Virus-induced Volatile Organic Compounds Are Detectable in Exhaled Breath during Pulmonary Infection

• Published in: American journal of respiratory and critical care medicine Vol. 204; no. 9; pp. 1075 - 1085
• Main Authors: Kamal, Faisal, Kumar, Sacheen, Edwards, Michael R., Veselkov, Kirill, Belluomo, Ilaria, Kebadze, Tatiana, Romano, Andrea, Trujillo-Torralbo, Maria-Belen, Shahridan Faiez, Tasnim, Walton, Ross, Ritchie, Andrew I., Wiseman, Dexter J., Laponogov, Ivan, Donaldson, Gavin, Wedzicha, Jadwiga A., Johnston, Sebastian L., Singanayagam, Aran, Hanna, George B.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.11.2021
• Subjects: Adult; Aged; Aged, 80 and over; Antibiotics; Antiviral drugs; Biomarkers; Biomarkers - analysis; Breath Tests - methods; Chronic obstructive pulmonary disease; Early Diagnosis; Female; Humans; Infections; Male; Middle Aged; Original; Picornaviridae Infections - diagnosis; Picornaviridae Infections - physiopathology; Pulmonary Disease, Chronic Obstructive - physiopathology; Respiratory diseases; Studies; VOCs; Volatile organic compounds; Volatile Organic Compounds - analysis; viral infection; volatile organic compound; rhinovirus; chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a condition punctuated by acute exacerbations commonly triggered by viral and/or bacterial infection. Early identification of exacerbation triggers is important to guide appropriate therapy, but currently available tests are slow and imprecise. Volatil...