New therapeutic protocol for improvement of endometrial receptivity (PRIMER) for patients with recurrent implantation failure (RIF) - A pilot study

• Published in: JBRA assisted reproduction Vol. 23; no. 3; pp. 250 - 254
• Main Authors: Dieamant, Felipe, Vagnini, Laura D., Petersen, Claudia G., Mauri, Ana L., Renzi, Adriana, Petersen, Bruna, Mattila, Mariana C., Nicoletti, Andreia, Oliveira, João Batista A., Baruffi, Ricardo, Franco Júnior, Jose G.
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction) 2019; Brazilian Society of Assisted Reproduction
• Subjects: Abortion, Habitual - pathology; Abortion, Habitual - therapy; Adult; Age; Blood Component Transfusion - methods; Blood platelets; Cell adhesion & migration; Cytokines; Defects; Embryo Implantation - drug effects; Embryo Implantation - physiology; Embryo Transfer - methods; Embryos; Endometrium - drug effects; Endometrium - pathology; Epidermal growth factor; Female; Fertilization in Vitro - methods; Granulocyte Colony-Stimulating Factor - therapeutic use; Humans; Infant, Newborn; Live Birth; Middle Aged; Miscarriage; Morphology; Original; Patients; Pilot Projects; Plasma; Platelet-Rich Plasma - physiology; Population; Pregnancy; Pregnancy Rate; Therapies, Investigational - methods; Treatment Failure; Ultrasonic imaging; Vascular endothelial growth factor; Brazil; recurrent implantation failure; granulocyte colony-stimulation factor; PRIMER; therapeutic protocol; endometrial receptivity; platelet-rich plasma

To evaluate whether or not one should use a new Protocol for Endometrial Receptivity Improvement (PRIMER) based on platelet-rich plasma (PRP) and granulocyte colony-stimulation factor (G-CSF) to enhance ongoing pregnancy rates in patients with recurrent implantation failure (RIF). Women undergoing I...