Nitrendipine and Superoxide Dismutase in Ischemic Renal Injury

• Published in: Renal failure Vol. 16; no. 6; pp. 697 - 705
• Main Authors: Jacobsen, Wayne K., Schell, Randall M., Matsumura, Jerry S., Cole, Daniel J., Stier, Gary R., Martin, Robert D., Fandrich, Bryan L.
• Format: Journal Article
• Language: English
• Published: Colchester Informa UK Ltd 01.01.1994; Taylor & Francis
• Subjects: Acute Kidney Injury - drug therapy; Acute Kidney Injury - etiology; Acute Kidney Injury - physiopathology; Animals; Biological and medical sciences; Creatinine - blood; Creatinine - urine; Drug Therapy, Combination; Ischemia - drug therapy; Ischemia - physiopathology; Kidney - blood supply; Kidney - drug effects; Kidney - physiopathology; Male; Medical sciences; Nitrendipine - therapeutic use; Pharmacology. Drug treatments; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase - therapeutic use; Urinary system; Animal model; Drug combination; Urinary system disease; Renal function; Rat; Enzyme; Acute; Rodentia; Calcium antagonist; Cardiovascular disease; Renal disease; Superoxide dismutase; Dihydropyridine derivative; Kidney; Result; Vascular disease; Vertebrata; Chemotherapy; Mammalia; Treatment; Ischemia; Animal; Renal failure; Oxidoreductases
• ISSN: 0886-022X; 1525-6049
• DOI: 10.3109/08860229409044899

The effect of the Ca entry blocker nitrendipine, the untioxidant superoxide dismutase (SOD), and a combination cf nitrendipine und superoxide dismutase on postischemic renal function was studied in four groups (n = 24) of rats. The rats in group I (n = 6) were the ischemic control and received 10 mL of 0.9% NaCl. Group II (n = 6) received SOD 7.0 mg/kg. Group III (n = 6) received nitrendipine 1 mg/kg. Group IV (n = 6) received nitrendipine 1 mg/kg and SOD 7 mg/kg, After administration, both kidneys were rendered ischemic by crossclamping the renal vessels for 60 min. Comparison of 24-h creatinine clearance (CCr) for 3 days after reversal og ischemia revealed: (a) nitrendipine alone was the most effective in preserving renal function (p <.05); (b) SOD provided some degree of improvement, but only on day 3 (p <.05); (c) a similar result was detected using a combination of nitrendipine and SOD (p <,05); (d) there was no significant difference between SOD and nitrendipine nor between SOD and the combination of nitrendipine/SOD; (e) there was a significant improvement with nitrendipine when compared to the combination of nitrendipine/SOD (p <. 05).