A Network of Sputum MicroRNAs Is Associated with Neutrophilic Airway Inflammation in Asthma

• Published in: American journal of respiratory and critical care medicine Vol. 202; no. 1; pp. 51 - 64
• Main Authors: Gomez, Jose L., Chen, Ailu, Diaz, Maria Paula, Zirn, Nicholas, Gupta, Amolika, Britto, Clemente, Sauler, Maor, Yan, Xiting, Stewart, Emma, Santerian, Kyle, Grant, Nicole, Liu, Qing, Fry, Rebecca, Rager, Julia, Cohn, Lauren, Alexis, Neil, Chupp, Geoffrey L.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.07.2020
• Subjects: Adult; Aged; Airway management; Asthma; Asthma - diagnosis; Asthma - genetics; Asthma - immunology; Biomarkers - metabolism; Case-Control Studies; Cross-Sectional Studies; Female; Gene Regulatory Networks; Genome-Wide Association Study; Healthy Volunteers; Humans; Male; Medical research; MicroRNAs; MicroRNAs - metabolism; Middle Aged; Neutrophils; Neutrophils - metabolism; Original; Phenotype; RNA, Messenger - metabolism; Severity of Illness Index; Sputum - metabolism; microRNAs; severe asthma; gene networks; TH17; hsa-miR-223-3p

MicroRNAs are potent regulators of biologic systems that are critical to tissue homeostasis. Individual microRNAs have been identified in airway samples. However, a systems analysis of the microRNA-mRNA networks present in the sputum that contribute to airway inflammation in asthma has not been publ...