Interplay Between Intestinal pH, Transit Time and Feed Status on the In Vivo Performance of pH Responsive Ileo-Colonic Release Systems

• Published in: Pharmaceutical research Vol. 25; no. 8; pp. 1828 - 1835
• Main Authors: Ibekwe, Valentine C., Fadda, Hala M., McConnell, Emma L., Khela, Mandeep K., Evans, David F., Basit, Abdul W.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.08.2008; Springer; Springer Nature B.V
• Subjects: Adult; Biochemistry; Biological and medical sciences; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Colon - physiology; Drug Delivery Systems; Drug dosages; Fasting - physiology; Food; Food-Drug Interactions - physiology; Gastric Emptying - physiology; Gastroenterology; Gastrointestinal Transit - physiology; General pharmacology; Humans; Hydrogen-Ion Concentration; Ileum - physiology; Indium Radioisotopes; Kinetics; Male; Medical Law; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacy; Polymethacrylic Acids; Research methodology; Research Paper; Tablets, Enteric-Coated; Technetium - pharmacokinetics; polymethacrylic acid methyl methacrylate ester copolymer; radiotelemetry; colonic delivery; enteric coating; inflammatory bowel disease; Performance evaluation; Inflammatory disease; Ester; pH; Intestinal disease; Tablet; Colon; Fast; Release; Human; Pharmaceutical technology; Oral administration; Enteric coating; Methyl methacrylate copolymer; Feeding; Digestive transit; Crohn disease; In vivo; Acids; Desintegration; Dosage form; Digestive diseases; Ulcerative colitis

Purpose Oral pH triggered drug delivery systems, for targeting to the lower gastrointestinal tract, show erratic behaviour in vivo . This study aimed to establish correlations between in situ gastrointestinal pH, transit time or feed status and the disintegration of pH-responsive dosage forms design...