Airway compliance measurements in mouse models of respiratory diseases

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 321; no. 1; pp. L204 - L212
• Main Authors: Robichaud, Annette, Fereydoonzad, Liah, Collins, Samuel L., Loube, Jeffrey Martin, Ishii, Yumiko, Horton, Maureen R., Martin, James G., Mitzner, Wayne
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.07.2021
• Subjects: Animal models; Bleomycin; Change detection; Compliance; Elastase; Emphysema; Fibrosis; Innovative Methodology; Leukotriene-C4 synthase; Respiratory diseases; Respiratory system; Respiratory tract; Respiratory tract diseases; airway compliance; fibrosis; LTC4 synthase; pressure-volume curves; emphysema

The quantification of airway compliance ( C aw ) is essential to the study of airway alterations in disease models. However, the required measurements of airway pressure and volume are difficult to acquire in mice. We hypothesized that the inflation limb of full-range pressure-volume (PV) curves cou...