Targeted delivery of TLR3 agonist to tumor cells with single chain antibody fragment-conjugated nanoparticles induces type I-interferon response and apoptosis

• Published in: Scientific reports Vol. 9; no. 1; p. 3299
• Main Authors: Schau, Isabell, Michen, Susanne, Hagstotz, Alexander, Janke, Andreas, Schackert, Gabriele, Appelhans, Dietmar, Temme, Achim
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.03.2019; Nature Publishing Group UK
• Subjects: Apoptosis; Bladder cancer; Cancer; Double-stranded RNA; Immune response; Immunoconjugates; Innate immunity; Interferon; Nanoparticles; Nucleic acids; Pharmacokinetics; TLR3 protein; Toll-like receptors; Tumor cells; Tumors; Xenografts

Application of Toll-like receptor (TLR) agonists is a promising approach to treat cancer. In particular, nucleic acid-based TLR agonists such as short ssRNA and dsRNA molecules, which activate endosomal TLRs, can be delivered to tumors by use of nanoparticle delivery systems. However, such delivery...