Aβ1–42 oligomer induces alteration of tight junction scaffold proteins via RAGE-mediated autophagy in bEnd.3 cells

• Published in: Experimental cell research Vol. 369; no. 2; pp. 266 - 274
• Main Authors: Chan, Yuanjin, Chen, Wenjing, Wan, Wenbin, Chen, Yanjie, Li, Yaming, Zhang, Chunyan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.08.2018
• Subjects: 60 APPLIED LIFE SCIENCES; ACTIN; Alzheimer's disease; Amyloid β; Autophagy; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARIES; PEPTIDES; Receptor for Advanced Glycation End Products (RAGE); RECEPTORS; Tight junctions; Receptor for Advanced Glycation End Products (RAGE); Blood-brain barrier; Tight junctions; Alzheimer's disease; Autophagy; Amyloid β

Compelling evidences have shown that amyloid-β (Aβ) peptide is one of the major pathogenic factors resulting in blood-brain barrier (BBB) disruption in Alzheimer's disease (AD). However, the mechanism underlying BBB breakdown remains elusive. In our present study, we employed murine brain capil...