EEG reveals that dextroamphetamine improves cognitive control through multiple processes in healthy participants

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 47; no. 5; pp. 1029 - 1036
• Main Authors: Bhakta, Savita G., Cavanagh, James F., Talledo, Jo A., Kotz, Juliana E., Benster, Lindsay, Roberts, Benjamin Z., Nungaray, John A., Brigman, Jonathan L., Light, Gregory A., Swerdlow, Neal R., Young, Jared W.
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.04.2022; Springer International Publishing
• Subjects: Adult; Biomarkers; Clinical trials; Cognition; Cognitive ability; Dextroamphetamine - pharmacology; EEG; Electroencephalography; Healthy Volunteers; Humans; Mental disorders; Reaction time task; Schizophrenia; Visual evoked potentials

The poor translatability between preclinical and clinical drug trials has limited pro-cognitive therapeutic development. Future pro-cognitive drug trials should use translatable cross-species cognitive tasks with biomarkers (1) relevant to specific cognitive constructs, and (2) sensitive to drug tre...