Neuroprotective effects of Quercetin on radiation-induced brain injury in rats
Extensive research has been focused on radiation-induced brain injury. Animal and human studies have shown that flavonoids have remarkable toxicological profiles. This study aims to investigate the neuroprotective effects of quercetin in an experimental radiation-induced brain injury. A total of 32...
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| Published in | Journal of radiation research Vol. 59; no. 4; pp. 404 - 410 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Oxford University Press
01.07.2018
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| Abstract | Extensive research has been focused on radiation-induced brain injury. Animal and human studies have shown that flavonoids have remarkable toxicological profiles. This study aims to investigate the neuroprotective effects of quercetin in an experimental radiation-induced brain injury. A total of 32 adult male Wistar-Albino rats were randomly divided into four groups (control, quercetin, radiation, and radiation+quercetin groups, with eight rats in each group). Doses (50 mg/kg) of quercetin were administered to the animals in the quercetin and radiation+quercetin groups; radiation and radiation+quercetin groups were exposed to a dose of 20 Gy to the cranium region. Tissue samples, and biochemical levels of tissue injury markers in the four groups were compared. In all measured parameters of oxidative stress, administration of quercetin significantly demonstrated favorable effects. Both plasma and tissue levels of malondialdehyde and total antioxidant status significantly changed in favor of antioxidant activity. Histopathological evaluation of the tissues also demonstrated a significant decrease in cellular degeneration and infiltration parameters after quercetin administration. Quercetin demonstrated significant neuroprotection after radiation-induced brain injury. Further studies of neurological outcomes under different experimental settings are required in order to achieve conclusive results. |
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| AbstractList | Extensive research has been focused on radiation-induced brain injury. Animal and human studies have shown that flavonoids have remarkable toxicological profiles. This study aims to investigate the neuroprotective effects of quercetin in an experimental radiation-induced brain injury. A total of 32 adult male Wistar-Albino rats were randomly divided into four groups (control, quercetin, radiation, and radiation+quercetin groups, with eight rats in each group). Doses (50 mg/kg) of quercetin were administered to the animals in the quercetin and radiation+quercetin groups; radiation and radiation+quercetin groups were exposed to a dose of 20 Gy to the cranium region. Tissue samples, and biochemical levels of tissue injury markers in the four groups were compared. In all measured parameters of oxidative stress, administration of quercetin significantly demonstrated favorable effects. Both plasma and tissue levels of malondialdehyde and total antioxidant status significantly changed in favor of antioxidant activity. Histopathological evaluation of the tissues also demonstrated a significant decrease in cellular degeneration and infiltration parameters after quercetin administration. Quercetin demonstrated significant neuroprotection after radiation-induced brain injury. Further studies of neurological outcomes under different experimental settings are required in order to achieve conclusive results. Extensive research has been focused on radiation-induced brain injury. Animal and human studies have shown that flavonoids have remarkable toxicological profiles. This study aims to investigate the neuroprotective effects of quercetin in an experimental radiation-induced brain injury. A total of 32 adult male Wistar-Albino rats were randomly divided into four groups (control, quercetin, radiation, and radiation+quercetin groups, with eight rats in each group). Doses (50 mg/kg) of quercetin were administered to the animals in the quercetin and radiation+quercetin groups; radiation and radiation+quercetin groups were exposed to a dose of 20 Gy to the cranium region. Tissue samples, and biochemical levels of tissue injury markers in the four groups were compared. In all measured parameters of oxidative stress, administration of quercetin significantly demonstrated favorable effects. Both plasma and tissue levels of malondialdehyde and total antioxidant status significantly changed in favor of antioxidant activity. Histopathological evaluation of the tissues also demonstrated a significant decrease in cellular degeneration and infiltration parameters after quercetin administration. Quercetin demonstrated significant neuroprotection after radiation-induced brain injury. Further studies of neurological outcomes under different experimental settings are required in order to achieve conclusive results.Extensive research has been focused on radiation-induced brain injury. Animal and human studies have shown that flavonoids have remarkable toxicological profiles. This study aims to investigate the neuroprotective effects of quercetin in an experimental radiation-induced brain injury. A total of 32 adult male Wistar-Albino rats were randomly divided into four groups (control, quercetin, radiation, and radiation+quercetin groups, with eight rats in each group). Doses (50 mg/kg) of quercetin were administered to the animals in the quercetin and radiation+quercetin groups; radiation and radiation+quercetin groups were exposed to a dose of 20 Gy to the cranium region. Tissue samples, and biochemical levels of tissue injury markers in the four groups were compared. In all measured parameters of oxidative stress, administration of quercetin significantly demonstrated favorable effects. Both plasma and tissue levels of malondialdehyde and total antioxidant status significantly changed in favor of antioxidant activity. Histopathological evaluation of the tissues also demonstrated a significant decrease in cellular degeneration and infiltration parameters after quercetin administration. Quercetin demonstrated significant neuroprotection after radiation-induced brain injury. Further studies of neurological outcomes under different experimental settings are required in order to achieve conclusive results. |
| Author | Can, Murat Elmas, Özlem Aydın, Bengü Gülhan Baş, Yılmaz Kale, Aydemir Büyükuysal, Çağatay Pişkin, Özcan |
| AuthorAffiliation | 5 Department of Radiation Oncology, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey 2 Department of Anesthesiology and Reanimation, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey 1 Department of Neurosurgery, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey 4 Department of Biochemistry, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey 6 Department of Biostatistics, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey 3 Department of Pathology, Hitit University Faculty of Medicine, Çorum, Turkey |
| AuthorAffiliation_xml | – name: 4 Department of Biochemistry, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey – name: 6 Department of Biostatistics, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey – name: 1 Department of Neurosurgery, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey – name: 3 Department of Pathology, Hitit University Faculty of Medicine, Çorum, Turkey – name: 2 Department of Anesthesiology and Reanimation, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey – name: 5 Department of Radiation Oncology, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey |
| Author_xml | – sequence: 1 givenname: Aydemir surname: Kale fullname: Kale, Aydemir organization: Department of Neurosurgery, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey – sequence: 2 givenname: Özcan surname: Pişkin fullname: Pişkin, Özcan organization: Department of Anesthesiology and Reanimation, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey – sequence: 3 givenname: Yılmaz surname: Baş fullname: Baş, Yılmaz organization: Department of Pathology, Hitit University Faculty of Medicine, Çorum, Turkey – sequence: 4 givenname: Bengü Gülhan surname: Aydın fullname: Aydın, Bengü Gülhan organization: Department of Anesthesiology and Reanimation, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey – sequence: 5 givenname: Murat surname: Can fullname: Can, Murat organization: Department of Biochemistry, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey – sequence: 6 givenname: Özlem surname: Elmas fullname: Elmas, Özlem organization: Department of Radiation Oncology, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey – sequence: 7 givenname: Çağatay surname: Büyükuysal fullname: Büyükuysal, Çağatay organization: Department of Biostatistics, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29688418$$D View this record in MEDLINE/PubMed |
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| Copyright | The Author(s) 2018. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Author(s) 2018. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. 2018 |
| Copyright_xml | – notice: The Author(s) 2018. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: The Author(s) 2018. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. 2018 |
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| SubjectTerms | Antioxidants Brain Cranium Degeneration Flavonoids Head injuries Parameters Radiation Radiation effects Radiation injuries Regular Paper Traumatic brain injury |
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| Title | Neuroprotective effects of Quercetin on radiation-induced brain injury in rats |
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