in vitro study of the toxic effects of Stachybotrys chartarum metabolites on lung cells

• Published in: Alternatives to laboratory animals Vol. 35; no. 1; pp. 47 - 52
• Main Authors: Kovacikova, Z, Tatrai, E, Pieckova, E, Tulinska, J, Pivovarova, Z, Matausic-Pisl, M, Kuricova, M, Wsolova, L
• Format: Journal Article
• Language: English
• Published: England 01.03.2007
• Subjects: Acid Phosphatase - metabolism; Alkaline Phosphatase - metabolism; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Epithelial Cells - drug effects; Epithelial Cells - metabolism; in vitro studies; lungs; Macrophages, Alveolar - drug effects; Macrophages, Alveolar - metabolism; Mycotoxins - isolation & purification; Mycotoxins - toxicity; Plant Lectins - metabolism; Pulmonary Alveoli - drug effects; Pulmonary Alveoli - metabolism; Rabbits; Rats; Stachybotrys; Stachybotrys - chemistry; toxicity testing

During a study of indoor fungal colonisation, several isolates of Stachybotrys chartarum were recovered, and the effects of metabolites from four isolates on lung epithelial Type II cells and alveolar macrophages were studied in vitro. All the isolates showed toxic effects on both cell types, and th...