Obesity modulates diaphragm curvature in subjects with and without COPD

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 313; no. 5; pp. R620 - R629
• Main Authors: Boriek, Aladin M., Lopez, Michael A., Velasco, Cristina, Bakir, Azam A., Frolov, Anna, Wynd, Shari, Babb, Tony G., Hanania, Nicola A., Hoffman, Eric A., Sharafkhaneh, Amir
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.11.2017
• Series: Respiration
• Subjects: Aged; Body Mass Index; Body size; Breathing; Case-Control Studies; Chest; Chronic obstructive pulmonary disease; Comorbidity; Computation; Computed tomography; Cross-Sectional Studies; Curvature; Diaphragm; Diaphragm (anatomy); Diaphragm - diagnostic imaging; Diaphragm - physiopathology; Female; Forced Expiratory Volume; Functional Residual Capacity; Humans; Insertion; Iowa; Lung - diagnostic imaging; Lung - physiopathology; Lung diseases; Male; Middle Aged; Models, Biological; Muscles; Obesity; Obesity - complications; Obesity - diagnosis; Obesity - physiopathology; Obstructive lung disease; Pulmonary Disease, Chronic Obstructive - complications; Pulmonary Disease, Chronic Obstructive - diagnostic imaging; Pulmonary Disease, Chronic Obstructive - physiopathology; Respiratory Mechanics; Severity of Illness Index; Texas; Tomography, X-Ray Computed; Total Lung Capacity; Vital Capacity; obesity; respiratory mechanics; emphysema

Obesity is a common comorbidity of chronic obstructive pulmonary disease (COPD) and has been associated with worse outcomes. However, it is unknown whether the interaction between obesity and COPD modulates diaphragm shape and consequently its function. The body mass index (BMI) has been used as a c...