RNA silencing and genome regulation

• Published in: Trends in cell biology Vol. 15; no. 5; pp. 251 - 258
• Main Authors: Almeida, Ricardo, Allshire, Robin C.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2005
• Subjects: Animals; Centromere - genetics; DNA Transposable Elements - genetics; DNA, Viral - genetics; Epigenesis, Genetic; Gene Expression Regulation; Genome; Heterochromatin - genetics; Humans; MicroRNAs - genetics; Models, Genetic; Repetitive Sequences, Nucleic Acid; RNA Interference; Schizosaccharomyces - genetics

Closely related RNA silencing phenomena such as posttranscriptional and transcriptional gene silencing (PTGS and TGS), quelling and RNA interference (RNAi) represent different forms of a conserved ancestral process. The biological relevance of these RNA-directed mechanisms of silencing in gene regul...