RNA silencing and genome regulation

Closely related RNA silencing phenomena such as posttranscriptional and transcriptional gene silencing (PTGS and TGS), quelling and RNA interference (RNAi) represent different forms of a conserved ancestral process. The biological relevance of these RNA-directed mechanisms of silencing in gene regul...

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Bibliographic Details
Published inTrends in cell biology Vol. 15; no. 5; pp. 251 - 258
Main Authors Almeida, Ricardo, Allshire, Robin C.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.05.2005
Subjects
Animals
Centromere - genetics
DNA Transposable Elements - genetics
DNA, Viral - genetics
Epigenesis, Genetic
Gene Expression Regulation
Genome
Heterochromatin - genetics
Humans
MicroRNAs - genetics
Models, Genetic
Repetitive Sequences, Nucleic Acid
RNA Interference
Schizosaccharomyces - genetics
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Summary:Closely related RNA silencing phenomena such as posttranscriptional and transcriptional gene silencing (PTGS and TGS), quelling and RNA interference (RNAi) represent different forms of a conserved ancestral process. The biological relevance of these RNA-directed mechanisms of silencing in gene regulation, genome defence and chromosomal structure is rapidly being unravelled. Here, we review the recent developments in the field of RNA silencing in relation to other epigenetic phenomena and discuss the significance of this process and its targets in the regulation of modern eukaryotic genomes.
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ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2005.03.006