Consensus Report on Shigella Controlled Human Infection Model Clinical Endpoints

• Published in: Clinical infectious diseases Vol. 69; no. Supplement_8; pp. S591 - S595
• Main Authors: MacLennan, Calman A., Riddle, Mark S., Chen, Wilbur H., Talaat, Kawsar R., Jain, Varsha, Bourgeois, A. Louis, Frenck, Robert, Kotloff, Karen, Porter, Chad K.
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 09.12.2019
• Subjects: Clinical Trials as Topic - standards; Consensus; Consensus Development Conferences as Topic; Drug Development - standards; Dysentery, Bacillary - prevention & control; Endpoint Determination - standards; Humans; Models, Biological; Research Report; Shigella - immunology; Shigella Vaccines - immunology; Shigella Vaccines - standards; Supplement; SUPPLEMENT ARTICLES; United States; United States; human infection studies; endpoints; controlled human infection model; Shigella

The Shigella controlled human infection model (CHIM) is valuable for assessing candidate Shigella vaccine efficacy and potentially accelerating regulatory approval. The Shigella CHIM is currently being conducted at 3 sites in the United States using Shigella flexneri 2a strain 2457T and Shigella son...