Influence of formulation variables on the in-vitro release of albumin from biodegradable microparticulate systems

• Published in: Journal of microencapsulation Vol. 14; no. 3; p. 349
• Main Authors: Igartua, M, Hernández, R M, Esquisabel, A, Gascon, A R, Calvo, M B, Pedraz, J L
• Format: Journal Article
• Language: English
• Published: England 1997
• Subjects: Biocompatible Materials; Biodegradation, Environmental; Calorimetry, Differential Scanning; Capsules; Emulsions; Freeze Drying; Kinetics; Lactic Acid; Particle Size; Polyglycolic Acid; Polymers; Serum Albumin, Bovine - chemistry; Surface Properties

Poly(D,L-lactide-co-glycolide) microspheres containing BSA were prepared by a modified solvent evaporation method using a double emulsion. These microspheres were characterized for size, morphology, surface absorbed protein, encapsulation efficiency and release kinetics. The influence of two formula...