Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage

• Published in: Cell death & disease Vol. 8; no. 7; p. e2951
• Main Authors: Nashine, Sonali, Cohen, Pinchas, Chwa, Marilyn, Lu, Stephanie, Nesburn, Anthony B, Kuppermann, Baruch D, Kenney, M Cristina
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.07.2017; Nature Publishing Group
• Subjects: 13; 13/2; 13/31; 13/51; 14; 14/19; 14/34; 38; 38/39; 38/77; 38/90; 631/45/612/1234; 631/80/642/333; 631/80/82; 692/699/3161/1626; 82; 82/1; 82/29; 96; 96/106; 96/2; Aged; Antibodies; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell Survival; Female; Humans; Immunology; Intracellular Signaling Peptides and Proteins - metabolism; Life Sciences; Macular Degeneration - metabolism; Macular Degeneration - pathology; Macular Degeneration - prevention & control; Male; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial Proteins - metabolism; Original; original-article; Retinal Pigment Epithelium - metabolism; Retinal Pigment Epithelium - pathology

Age-related macular degeneration (AMD) ranks third among the leading causes of visual impairment with a blindness prevalence rate of 8.7%. Despite several treatment regimens, such as anti-angiogenic drugs, laser therapy, and vitamin supplementation, being available for wet AMD, to date there are no...