Combined control of the fibroblast contractile program by YAP and TAZ

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 322; no. 1; pp. L23 - L32
• Main Authors: Link, Patrick A, Choi, Kyoung Moo, Diaz Espinosa, Ana M, Jones, Dakota L, Gao, Ashley Y, Haak, Andrew J, Tschumperlin, Daniel J
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.01.2022
• Subjects: Biomechanical Phenomena - drug effects; Cell Line; Cofactors; Contractility; Cytoskeleton; DNA microarrays; Fibroblasts; Fibroblasts - drug effects; Fibroblasts - metabolism; Fibrosis; Gene expression; Gene Expression Regulation - drug effects; Genes; Growth factors; Humans; Lung diseases; Lungs; Redundancy; RNA, Messenger - genetics; RNA, Messenger - metabolism; Transcription activation; Transcriptional Coactivator with PDZ-Binding Motif Proteins - metabolism; Transforming Growth Factor beta1 - pharmacology; Transforming growth factor-b1; Wound healing; YAP-Signaling Proteins - metabolism; Yes-associated protein; contraction; fibroblast; idiopathic pulmonary fibrosis; YAP/TAZ; mechanotransduction

Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are transcription cofactors implicated in the contractile and profibrotic activation of fibroblasts. Fibroblast contractile function is important in alveologenesis and in lung wound healing and fibrosis. As par...