Organoruthenium(II) Complexes Ameliorates Oxidative Stress and Impedes the Age Associated Deterioration in Caenorhabditis elegans through JNK-1/DAF-16 Signalling

• Published in: Scientific reports Vol. 8; no. 1; pp. 7688 - 15
• Main Authors: Devagi, G, Mohankumar, A, Shanmugam, G, Nivitha, S, Dallemer, F, Kalaivani, P, Sundararaj, P, Prabhakaran, R
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 16.05.2018; Nature Publishing Group UK
• Subjects: Age; Aging; Antioxidants; Biological activity; Caenorhabditis elegans; Cancer; Disease; Gene expression; Heat shock proteins; Kinases; Ligands; Nematodes; Oxidative stress; Transcription factors
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-25984-7

New ruthenium(II) complexes were synthesised and characterized by various spectro analytical techniques. The structure of the complexes 3 and 4 has been confirmed by X-ray crystallography. The complexes were subjected to study their anti-oxidant profile and were exhibited significantly greater in vitro DPPH radical scavenging activity than vitamin C. We found that complexes 1-4 confered tolerance to oxidative stress and extend the mean lifespan of mev-1 mutant worms and wild-type Caenorhabditis elegans. Further, mechanistic study and reporter gene expression analysis revealed that Ru(ƞ -p-cymene) complexes maintained the intracellular redox status and offers stress resistance through activating JNK-1/DAF-16 signaling axis and possibly by other antioxidant response pathway. Notably, complex 3 and 4 ameliorates the polyQ (a Huntington's disease associated protein) mediated proteotoxicity and related behavioural deficits in Huntington's disease models of C. elegans. From these observations, we hope that new Ru(ƞ -p-cymene) complexes could be further considered as a potential drug to retard aging and age-related neurodegenerative diseases.