Biomimetic O2-Evolving metal-organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic tumor

• Published in: Biomaterials Vol. 178; pp. 83 - 94
• Main Authors: Gao, Shutao, Zheng, Pengli, Li, Zhenhua, Feng, Xiaochen, Yan, Weixiao, Chen, Shizhu, Guo, Weisheng, Liu, Dandan, Yang, Xinjian, Wang, Shuxiang, Liang, Xing-Jie, Zhang, Jinchao
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.09.2018
• Subjects: biomimetics; coordination compounds; erythrocytes; hypoxia; irradiation; Long circulation; Metal-organic framework; neoplasms; O2-evolving; oxygen; photochemotherapy; Photodynamic therapy; photosensitizing agents; RBC membrane; singlet oxygen; zirconium; Metal-organic framework; Long circulation; Photodynamic therapy; RBC membrane; O2-evolving

Improving the supply of O2 and the circulation lifetime of photosensitizers for photodynamic therapy (PDT) in vivo would be a promising approach to eliminate hypoxic tumors. Herein, by taking advantage of the significant gas-adsorption capability of metal-organic frameworks (MOFs), a biomimetic O2-e...