New Labyrinth Microfluidic Device Detects Circulating Tumor Cells Expressing Cancer Stem Cell Marker and Circulating Tumor Microemboli in Hepatocellular Carcinoma

• Published in: Scientific reports Vol. 9; no. 1; pp. 18575 - 11
• Main Authors: Wan, Shanshan, Kim, Tae Hyun, Smith, Kaylee J, Delaney, Ryan, Park, G-Su, Guo, Hui, Lin, Eric, Plegue, Thomas, Kuo, Ning, Steffes, John, Leu, Christopher, Simeone, Diane M, Razimulava, Nataliya, Parikh, Neehar D, Nagrath, Sunitha, Welling, Theodore H
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 09.12.2019; Nature Publishing Group UK
• Subjects: Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Hepatocellular - blood; CD44 antigen; Cell survival; Disease Progression; Drug Resistance, Neoplasm; Embolism - metabolism; Hep G2 Cells; Hepatocellular carcinoma; Humans; Lab-On-A-Chip Devices; Liver cancer; Liver Neoplasms - blood; Metastases; Microfluidics; Microscopy, Fluorescence; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplastic Cells, Circulating - metabolism; Neoplastic Stem Cells - cytology; Peripheral blood; Stem cells; Translational Medical Research; Treatment Outcome; Tumor cells; Tumors

Hepatocellular Carcinoma (HCC) is one of the most lethal cancers with a high mortality and recurrence rate. Circulating tumor cell (CTC) detection offers various opportunities to advance early detection and monitoring of HCC tumors which is crucial for improving patient outcome. We developed and opt...