Relationship between intermuscular adipose tissue infiltration and myostatin before and after aerobic exercise training

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 315; no. 3; pp. R461 - R468
• Main Authors: Konopka, Adam R., Wolff, Christopher A., Suer, Miranda K., Harber, Matthew P.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.09.2018
• Series: Physical Activity and Inactivity
• Subjects: Adipose tissue; Adipose Tissue - diagnostic imaging; Adipose Tissue - physiology; Adiposity; Aerobics; Age Factors; Aged; Animal models; Bicycling; Biomarkers; Biopsy; Body weight; Cell culture; Cyclin-dependent kinase 2; Cyclin-Dependent Kinase 2 - metabolism; Exercise - physiology; Exercise Test; Female; Humans; Infiltration; Kinases; Magnetic Resonance Imaging; Male; Muscle Contraction; Muscle function; Muscle Strength; Muscle, Skeletal - diagnostic imaging; Muscle, Skeletal - metabolism; Muscles; Myostatin; Myostatin - metabolism; Phosphorylation; Physical training; Proteins; Reduction; Sedentary Behavior; Skeletal muscle; Time Factors; Training; Tyrosine; Womens health; Young Adult; aging; skeletal muscle; IMAT; hypertrophy; noncontractile tissue

Intermuscular adipose tissue (IMAT) is associated with impaired skeletal muscle contractile and metabolic function. Myostatin and downstream signaling proteins such as cyclin-dependent kinase 2 (CDK2) contribute to the regulation of adipose and skeletal muscle mass in cell culture and animals models...