Areca Nut Induces miR-23a and Inhibits Repair of DNA Double-Strand Breaks by Targeting FANCG

• Published in: Toxicological sciences Vol. 123; no. 2; pp. 480 - 490
• Main Authors: Tsai, Yi-Shan, Lin, Chang-Shen, Chiang, Shang-Lun, Lee, Chien-Hung, Lee, Ka-Wo, Ko, Ying-Chin
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.10.2011
• Subjects: Areca - chemistry; Arecoline - toxicity; Cell Line, Tumor; DNA Breaks, Double-Stranded - drug effects; DNA Repair - drug effects; Fanconi Anemia Complementation Group G Protein - genetics; Fanconi Anemia Complementation Group G Protein - metabolism; Fibroblasts - drug effects; Fibroblasts - metabolism; Gene Knockdown Techniques; Gingiva - drug effects; Gingiva - metabolism; Gingival Neoplasms - drug therapy; Gingival Neoplasms - metabolism; Histones - genetics; Histones - metabolism; Humans; MicroRNAs - biosynthesis; MicroRNAs - genetics; Plant Extracts - toxicity; microRNA; double-strand breaks repair; miR-23a; network-based analyses; FANCG; areca nut

Previous investigations have shown that areca nut extracts (ANE) or arecoline (ARE) causes DNA damage, which in turn contributes to oral cell carcinogenesis. To understand the role of microRNA (miRNA) in ANE-associated carcinogenesis, miRNA expression profile was examined in ANE-treated normal human...