Sporadic Colon Cancer: Mismatch Repair Immunohistochemistry and Microsatellite Instability in Omani Subjects

• Published in: Digestive diseases and sciences Vol. 53; no. 10; pp. 2723 - 2731
• Main Authors: Ashktorab, Hassan, Brim, Hassan, Al-Riyami, Marwa, Date, Anand, Al-Mawaly, Kamla, Kashoub, Masoud, Al-Mjeni, Rayhaneh, Smoot, Duane T., AL-Moundhri, Mansoor, Al-Hashemi, Suleiman, Ganguly, Shyam S., Raeburn, Sandy
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.10.2008; Springer; Springer Nature B.V
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Adenoma - ethnology; Adenoma - genetics; Adenoma - metabolism; Adult; Aged; Aged, 80 and over; Biochemistry; Biological and medical sciences; Colonic Neoplasms - ethnology; Colonic Neoplasms - genetics; Colonic Neoplasms - metabolism; Colorectal Neoplasms - ethnology; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; DNA Mismatch Repair; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Hepatology; Humans; Kaplan-Meier Estimate; Male; Medical sciences; Medicine; Medicine & Public Health; Microsatellite Instability; Middle Aged; Mucins - metabolism; MutL Protein Homolog 1; MutS Homolog 2 Protein - genetics; MutS Homolog 2 Protein - metabolism; Neoplasm Staging; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Oman; Oncology; Original Paper; Retrospective Studies; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Transplant Surgery; Tumors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Asia; Oman; MSI; MSP; p16; CRC; Oman; Human; Immunohistochemistry; Sporadic; Metabolic diseases; Malignant tumor; Colonic disease; Anatomic pathology; Colon cancer; MSI, p16; Microsatellite DNA; Gastroenterology; Digestive diseases; Intestinal disease; Instability; CRC, Oman; Cancer

Background Colorectal carcinoma (CRC) is the most common gastrointestinal malignancy in the world, and there are suggestions of a particularly high incidence in the Middle East, including those of African origin. Defects in DNA mismatch repair (MMR) systems are involved in the carcinogenesis of both...