Tracking adiponectin biodistribution via fluorescence molecular tomography indicates increased vascular permeability after streptozotocin-induced diabetes

• Published in: American journal of physiology: endocrinology and metabolism Vol. 317; no. 5; pp. E760 - E772
• Main Authors: Yoon, Nanyoung, Dadson, Keith, Dang, Thanh, Chu, Teresa, Noskovicova, Nina, Hinz, Boris, Raignault, Adeline, Thorin, Eric, Kim, Seunggyu, Jeon, Jessie S, Jonkman, James, McKee, Trevor D, Grant, Justin, Peterson, Jeffrey D, Kelly, Scott P, Sweeney, Gary
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.11.2019
• Series: Translational Physiology
• Subjects: Adiponectin; Adiponectin - metabolism; Animals; Capillary Permeability; Cardiovascular diseases; Cell Line; Computed tomography; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - pathology; Endothelial cells; Endothelial Cells - metabolism; Endothelium; Energy metabolism; Fluorescence; Gene Knockdown Techniques; Glucose; Glucose - pharmacology; Heart; Humans; Immunohistochemistry; Inserts; Liver - metabolism; Male; Menopause; Mice; Mice, Inbred C57BL; Microcirculation; Microfluidics; Microvasculature; Myocardium - metabolism; Permeability; Rats; Rats, Wistar; siRNA; Streptozocin; Tissue Distribution; Tissues; Tomography - methods; Tomography, X-Ray Computed; adiponectin; vascular permeability; diabetes; endothelial; fluorescence molecular tomography; heart

Adiponectin, a highly abundant polypeptide hormone in plasma, plays an important role in the regulation of energy metabolism in a wide variety of tissues, as well as providing important beneficial effects in diabetes, inflammation, and cardiovascular disease. To act on target tissues, adiponectin mu...