Surfactant protein D is a candidate biomarker for subclinical tobacco smoke-induced lung damage

Variation in surfactant protein D (SP-D) is associated with lung function in tobacco smoke-induced chronic respiratory disease. We hypothesized that the same association exists in the general population and could be used to identify individuals sensitive to smoke-induced lung damage. The association...

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Published inAmerican journal of physiology. Lung cellular and molecular physiology Vol. 306; no. 9; pp. L887 - L895
Main Authors Johansson, Sofie L, Tan, Qihua, Holst, René, Christiansen, Lene, Hansen, Niels C G, Hojland, Allan T, Wulf-Johansson, Helle, Schlosser, Anders, Titlestad, Ingrid L, Vestbo, Jørgen, Holmskov, Uffe, Kyvik, Kirsten O, Sorensen, Grith L
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Published United States American Physiological Society 01.05.2014
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Abstract Variation in surfactant protein D (SP-D) is associated with lung function in tobacco smoke-induced chronic respiratory disease. We hypothesized that the same association exists in the general population and could be used to identify individuals sensitive to smoke-induced lung damage. The association between serum SP-D (sSP-D) and expiratory lung function was assessed in a cross-sectional design in a Danish twin population (n = 1,512, 18-72 yr old). The adjusted heritability estimates for expiratory lung function, associations between SP-D gene (SFTPD) single-nucleotide polymorphisms or haplotypes, and expiratory lung function were assessed using twin study methodology and mixed-effects models. Significant inverse associations were evident between sSP-D and the forced expiratory volume in 1 s and forced vital capacity in the presence of current tobacco smoking but not in nonsmokers. The two SFTPD single-nucleotide polymorphisms, rs1923536 and rs721917, and haplotypes, including these single-nucleotide polymorphisms or rs2243539, were inversely associated with expiratory lung function in interaction with smoking. In conclusion, SP-D is phenotypically and genetically associated with lung function measures in interaction with tobacco smoking. The obtained data suggest sSP-D as a candidate biomarker in risk assessments for subclinical tobacco smoke-induced lung damage. The data and derived conclusion warrant confirmation in a longitudinal population following chronic obstructive pulmonary disease initiation and development.
AbstractList Variation in surfactant protein D (SP-D) is associated with lung function in tobacco smoke-induced chronic respiratory disease. We hypothesized that the same association exists in the general population and could be used to identify individuals sensitive to smoke-induced lung damage. The association between serum SP-D (sSP-D) and expiratory lung function was assessed in a cross-sectional design in a Danish twin population (n = 1,512, 18-72 yr old). The adjusted heritability estimates for expiratory lung function, associations between SP-D gene (SFTPD) single-nucleotide polymorphisms or haplotypes, and expiratory lung function were assessed using twin study methodology and mixed-effects models. Significant inverse associations were evident between sSP-D and the forced expiratory volume in 1 s and forced vital capacity in the presence of current tobacco smoking but not in nonsmokers. The two SFTPD single-nucleotide polymorphisms, rs1923536 and rs721917, and haplotypes, including these single-nucleotide polymorphisms or rs2243539, were inversely associated with expiratory lung function in interaction with smoking. In conclusion, SP-D is phenotypically and genetically associated with lung function measures in interaction with tobacco smoking. The obtained data suggest sSP-D as a candidate biomarker in risk assessments for subclinical tobacco smoke-induced lung damage. The data and derived conclusion warrant confirmation in a longitudinal population following chronic obstructive pulmonary disease initiation and development. [PUBLICATION ABSTRACT]
Variation in surfactant protein D (SP-D) is associated with lung function in tobacco smoke-induced chronic respiratory disease. We hypothesized that the same association exists in the general population and could be used to identify individuals sensitive to smoke-induced lung damage. The association between serum SP-D (sSP-D) and expiratory lung function was assessed in a cross-sectional design in a Danish twin population (n = 1,512, 18-72 yr old). The adjusted heritability estimates for expiratory lung function, associations between SP-D gene (SFTPD) single-nucleotide polymorphisms or haplotypes, and expiratory lung function were assessed using twin study methodology and mixed-effects models. Significant inverse associations were evident between sSP-D and the forced expiratory volume in 1 s and forced vital capacity in the presence of current tobacco smoking but not in nonsmokers. The two SFTPD single-nucleotide polymorphisms, rs1923536 and rs721917, and haplotypes, including these single-nucleotide polymorphisms or rs2243539, were inversely associated with expiratory lung function in interaction with smoking. In conclusion, SP-D is phenotypically and genetically associated with lung function measures in interaction with tobacco smoking. The obtained data suggest sSP-D as a candidate biomarker in risk assessments for subclinical tobacco smoke-induced lung damage. The data and derived conclusion warrant confirmation in a longitudinal population following chronic obstructive pulmonary disease initiation and development.
Author Johansson, Sofie L
Titlestad, Ingrid L
Holst, René
Kyvik, Kirsten O
Christiansen, Lene
Hansen, Niels C G
Hojland, Allan T
Schlosser, Anders
Vestbo, Jørgen
Wulf-Johansson, Helle
Holmskov, Uffe
Sorensen, Grith L
Tan, Qihua
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lung injury
single-nucleotide polymorphisms
surfactant protein D
forced expiratory volume in one second
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Snippet Variation in surfactant protein D (SP-D) is associated with lung function in tobacco smoke-induced chronic respiratory disease. We hypothesized that the same...
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StartPage L887
SubjectTerms Adolescent
Adult
Aged
Biomarkers - analysis
Cross-Sectional Studies
Denmark
Female
Forced Expiratory Volume
Genetic Association Studies
Haplotypes
Haplotypes - genetics
Humans
Lung Diseases - chemically induced
Lung Diseases - diagnosis
Lung Diseases - genetics
Male
Middle Aged
Polymorphism
Polymorphism, Single Nucleotide - genetics
Prognosis
Proteins
Pulmonary Surfactant-Associated Protein D - genetics
Pulmonary Surfactants - metabolism
Respiratory diseases
Risk assessment
Smoking - adverse effects
Surfactants
Tobacco smoke
Vital Capacity
Young Adult
Title Surfactant protein D is a candidate biomarker for subclinical tobacco smoke-induced lung damage
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