Dose-Response Relationship to Inhaled Endotoxin in Normal Subjects

• Published in: American journal of respiratory and critical care medicine Vol. 156; no. 4; pp. 1157 - 1164
• Main Authors: MICHEL, OLIVIER, NAGY, ANNE-MARIE, SCHROEVEN, MARC, DUCHATEAU, JEAN, NÈVE, JEAN, FONDU, PIERRE, SERGYSELS, ROGER
• Format: Journal Article
• Language: English
• Published: New York, NY American Lung Association 01.10.1997
• Subjects: Administration, Inhalation; Adult; Biological and medical sciences; Biomarkers; Bronchi - cytology; Bronchi - drug effects; Bronchi - physiopathology; Bronchial Hyperreactivity - chemically induced; Bronchial Hyperreactivity - metabolism; Bronchial Hyperreactivity - physiopathology; C-Reactive Protein - metabolism; Chronic obstructive pulmonary disease, asthma; Dose-Response Relationship, Drug; Escherichia coli; Female; Humans; Interleukin-8 - metabolism; Leukocyte Count; Lipopolysaccharides - administration & dosage; Lipopolysaccharides - adverse effects; Macrophages, Alveolar - cytology; Male; Medical sciences; Middle Aged; Neutrophils - cytology; Peroxidase - metabolism; Pneumology; Reference Values; Respiratory Function Tests; Single-Blind Method; Sputum - cytology; Sputum - metabolism; Tumor Necrosis Factor-alpha - metabolism; Human; Respiratory disease; Lung; Exploration; Inflammation; Obstructive pulmonary disease; Endotoxin; Asthma; Inhalation; Dose activity relation

Exposure to endotoxin and to its purified derivative lipopolysaccharide (LPS) is related to several occupational pulmonary diseases and to severe domestic asthma. An inhalation of a given dose of pure LPS produces both a systemic and a bronchial inflammatory response. Information on the dose-respons...