Identification of Transcription Factors, Biological Pathways, and Diseases as Mediated by N6-methyladenosine Using Tensor Decomposition-Based Unsupervised Feature Extraction

• Published in: Applied sciences Vol. 11; no. 1; p. 213
• Main Authors: Taguchi, Y-h., Dharshini, S. Akila Parvathy, Gromiha, M. Michael
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.01.2021
• Subjects: Alzheimer's disease; Biological activity; Datasets; Decomposition; Diseases; Editing; Embryo cells; feature extraction; Gene expression; Genes; histone modification; Histones; N6-methyladenosine; RNA modification; Stem cell transplantation; Stem cells; tensor decomposition; Transcription factors

N6-methyladenosine (m6A) editing is the most common RNA modification known to contribute to various biological processes. Nevertheless, the mechanism by which m6A regulates transcription is unclear. Recently, it was proposed that m6A controls transcription through histone modification, although no c...