Pathogenesis and pathology of blackleg in ruminants: the role of toxins and neuraminidase. A short review

• Published in: The Veterinary quarterly Vol. 25; no. 4; p. 155
• Main Authors: Useh, N M, Nok, A J, Esievo, K A N
• Format: Journal Article
• Language: English
• Published: England 01.12.2003
• Subjects: Animals; Bacterial Toxins; Cattle; Cattle Diseases - microbiology; Cattle Diseases - pathology; Clostridium - enzymology; Clostridium - pathogenicity; Clostridium Infections - microbiology; Clostridium Infections - veterinary; Muscle, Skeletal - microbiology; Muscle, Skeletal - pathology; Neuraminidase
• ISSN: 0165-2176; 1875-5941
• DOI: 10.1080/01652176.2003.9695158

There is no consensus on the pathogenesis of blackleg infection that occurs in ruminants, but toxins and neuraminidase produced by Clostridium chauvoei are believed to play a significant role in the pathogenesis of the disease. This paper provides an update on the role of toxins and neuraminidase in the pathogenesis and pathology of the disease. The use of neuraminidase inhibitors to manage clinical blackleg infections is therefore an alternative therapeutic protocol that should be thoroughly investigated. It is suggested that in vivo clinical trials should be carried out to determine the mechanism of action and clinical efficacy of neuraminidase inhibitors.