Inhibition of red seabream iridovirus (RSIV) replication by small interfering RNA (siRNA) in a cell culture system

Small interfering RNAs (siRNAs), mediators of a process of sequence-specific gene silencing called RNA interference, have been shown to have activity against a wide range of viruses and are considered to be potential antiviral tools. Here, we describe an antiviral activity of a siRNA that targets th...

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Published inAntiviral research Vol. 77; no. 2; pp. 142 - 149
Main Authors Dang, Lua T., Kondo, Hidehiro, Hirono, Ikuo, Aoki, Takashi
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.02.2008
Elsevier
Subjects
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Base Sequence
Biological and medical sciences
Capsid Proteins - genetics
Capsid Proteins - metabolism
Cell Line
Cells, Cultured
Iridovirus
Iridovirus - genetics
Major capsid protein
MCP
Medical sciences
Pharmacology. Drug treatments
Plasmids
Red seabream iridovirus
Reverse Transcriptase Polymerase Chain Reaction
RNA Interference
RNA interference (RNAi)
RNA, Small Interfering - genetics
RSIV
Sea Bream - virology
Small interfering RNA (siRNA)
Transfection
Virus Replication - drug effects
RSIV
RNA interference (RNAi)
Small interfering RNA (siRNA)
MCP
Red seabream iridovirus
Major capsid protein
Cell culture
RNA interference
Pagrus major
siRNA
In vitro
Protein
Virus
Gene silencing
Vertebrata
Iridoviridae
Pisces
Replication
Cell system
Capsid
Veterinary
Iridovirus
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Abstract Small interfering RNAs (siRNAs), mediators of a process of sequence-specific gene silencing called RNA interference, have been shown to have activity against a wide range of viruses and are considered to be potential antiviral tools. Here, we describe an antiviral activity of a siRNA that targets the major capsid protein (MCP) gene of red seabream iridovirus (RSIV), a marine fish-pathogenic virus, in a cell culture system. Inhibition of RSIV replication was demonstrated by reduced MCP expression level and reduced RSIV titer. MCP-targeted siRNA (siR-MCP) dose-dependently inhibited the expression of MCP gene in cells that either transiently expressed or stably expressed the MCP gene. At 84 and 96 h after viral infection, siR-MCP reduced the expression of MCP gene by 55.2% and 97.1%, respectively. Transfection with siR-MCP reduced the production of RSIV particles in supernatants of samples infected with RSIV, while the corresponding mismatched siR-MCP (MsiR-MCP) and nsRNA controls did not exhibit this effect. These results show that MCP-targeted siRNA can effectively and specifically inhibit the expression of the target gene and hinder RSIV replication during an in vitro infection, providing a potential approach for the control of viral diseases in aquaculture.
AbstractList Small interfering RNAs (siRNAs), mediators of a process of sequence-specific gene silencing called RNA interference, have been shown to have activity against a wide range of viruses and are considered to be potential antiviral tools. Here, we describe an antiviral activity of a siRNA that targets the major capsid protein (MCP) gene of red seabream iridovirus (RSIV), a marine fish-pathogenic virus, in a cell culture system. Inhibition of RSIV replication was demonstrated by reduced MCP expression level and reduced RSIV titer. MCP-targeted siRNA (siR-MCP) dose-dependently inhibited the expression of MCP gene in cells that either transiently expressed or stably expressed the MCP gene. At 84 and 96h after viral infection, siR-MCP reduced the expression of MCP gene by 55.2% and 97.1%, respectively. Transfection with siR-MCP reduced the production of RSIV particles in supernatants of samples infected with RSIV, while the corresponding mismatched siR-MCP (MsiR-MCP) and nsRNA controls did not exhibit this effect. These results show that MCP-targeted siRNA can effectively and specifically inhibit the expression of the target gene and hinder RSIV replication during an in vitro infection, providing a potential approach for the control of viral diseases in aquaculture.
Small interfering RNAs (siRNAs), mediators of a process of sequence-specific gene silencing called RNA interference, have been shown to have activity against a wide range of viruses and are considered to be potential antiviral tools. Here, we describe an antiviral activity of a siRNA that targets the major capsid protein (MCP) gene of red seabream iridovirus (RSIV), a marine fish-pathogenic virus, in a cell culture system. Inhibition of RSIV replication was demonstrated by reduced MCP expression level and reduced RSIV titer. MCP-targeted siRNA (siR-MCP) dose-dependently inhibited the expression of MCP gene in cells that either transiently expressed or stably expressed the MCP gene. At 84 and 96 h after viral infection, siR-MCP reduced the expression of MCP gene by 55.2% and 97.1%, respectively. Transfection with siR-MCP reduced the production of RSIV particles in supernatants of samples infected with RSIV, while the corresponding mismatched siR-MCP (MsiR-MCP) and nsRNA controls did not exhibit this effect. These results show that MCP-targeted siRNA can effectively and specifically inhibit the expression of the target gene and hinder RSIV replication during an in vitro infection, providing a potential approach for the control of viral diseases in aquaculture.
Author Dang, Lua T.
Kondo, Hidehiro
Hirono, Ikuo
Aoki, Takashi
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Issue 2
Keywords RSIV
RNA interference (RNAi)
Small interfering RNA (siRNA)
MCP
Red seabream iridovirus
Major capsid protein
Cell culture
RNA interference
Pagrus major
siRNA
In vitro
Protein
Virus
Gene silencing
Vertebrata
Iridoviridae
Pisces
Replication
Cell system
Capsid
Veterinary
Iridovirus
Language English
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Snippet Small interfering RNAs (siRNAs), mediators of a process of sequence-specific gene silencing called RNA interference, have been shown to have activity against a...
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SubjectTerms Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Base Sequence
Biological and medical sciences
Capsid Proteins - genetics
Capsid Proteins - metabolism
Cell Line
Cells, Cultured
Iridovirus
Iridovirus - genetics
Major capsid protein
MCP
Medical sciences
Pharmacology. Drug treatments
Plasmids
Red seabream iridovirus
Reverse Transcriptase Polymerase Chain Reaction
RNA Interference
RNA interference (RNAi)
RNA, Small Interfering - genetics
RSIV
Sea Bream - virology
Small interfering RNA (siRNA)
Transfection
Virus Replication - drug effects
Title Inhibition of red seabream iridovirus (RSIV) replication by small interfering RNA (siRNA) in a cell culture system
URI https://dx.doi.org/10.1016/j.antiviral.2007.10.007
https://www.ncbi.nlm.nih.gov/pubmed/18037509
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