Ligustilide attenuates pain behavior induced by acetic acid or formalin

• Published in: Journal of ethnopharmacology Vol. 112; no. 1; pp. 211 - 214
• Main Authors: Du, Junrong, Yu, Yan, Ke, Ya, Wang, Chenyuen, Zhu, Li, Qian, Zhong Ming
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 30.05.2007; Elsevier
• Subjects: 4-Butyrolactone - analogs & derivatives; 4-Butyrolactone - therapeutic use; Acetic Acid; Acetic acid-induced writhing test; analgesic effect; Analgesics - therapeutic use; Animals; Biological and medical sciences; chemical constituents of plants; Danggui; Drugs, Chinese Herbal - therapeutic use; dysmenorrhoea; essential oils; ethnobotany; Female; Formaldehyde; Formalin test; General pharmacology; herbal medicines; Ligustilide (LIG); Medical sciences; medicinal plants; medicinal properties; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; muscle contraction; Oriental traditional medicine; Pain; Pain - chemically induced; Pain - drug therapy; Pain Measurement; parasympatholytics; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; plant extracts; Primary dysmenorrhoea; smooth muscle; uterine tissue; China; Asia; Japan; Danggui; Pain; Ligustilide (LIG); Primary dysmenorrhoea; Formalin test; Acetic acid-induced writhing test; Pharmacognosy; Oriental medicine; Lactone; Medicinal plant; Folk medicine; Dicotyledones; Angiospermae; Plant origin; Rhizome; Spermatophyta; Behavior; Umbelliferae; Acetic acid; Below ground plant part

Danggui is a popular traditional Chinese medicinal (TCM) herb, which has long been used clinically to treat primary dysmenorrhoea. In a recent study, we demonstrated that ligustilide (LIG), one of the main compounds of Danggui essential oil, has multiple effects on uterine smooth muscles and possess...