Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake

• Published in: Scientific reports Vol. 9; no. 1; p. 11416
• Main Authors: Banerjee, Sreemoti, Andrew, Robert J, Duff, Christopher J, Fisher, Kate, Jackson, Carolyn D, Lawrence, Catherine B, Maeda, Nobuyo, Greenspan, Daniel S, Kellett, Katherine A B, Hooper, Nigel M
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 06.08.2019; Nature Publishing Group UK
• Subjects: Animals; Atherosclerosis - blood; Atherosclerosis - drug therapy; Atherosclerosis - metabolism; Atherosclerosis - pathology; Biopsy; Bone density; Bone morphogenetic protein 1; Bone Morphogenetic Protein 1 - antagonists & inhibitors; Bone Morphogenetic Protein 1 - genetics; Bone Morphogenetic Protein 1 - metabolism; Cardiovascular diseases; CHO Cells; Cholesterol; Cricetulus; Gene Knockdown Techniques; Hep G2 Cells; Humans; Lipoproteins, LDL - blood; Lipoproteins, LDL - metabolism; Liver - chemistry; Liver - metabolism; Liver - pathology; Low density lipoprotein; Low density lipoprotein receptors; Metalloproteinase; Mice; Mice, Transgenic; Null cells; Oxadiazoles - pharmacology; Proteolysis; Proteolysis - drug effects; Receptor density; Receptors, LDL - analysis; Receptors, LDL - genetics; Receptors, LDL - metabolism; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; RNA, Small Interfering - metabolism; siRNA; Zinc metalloproteinase

The development of cardiovascular disease is intimately linked to elevated levels of low-density lipoprotein (LDL) cholesterol in the blood. Hepatic LDL receptor (LDLR) levels regulate the amount of plasma LDL. We identified the secreted zinc metalloproteinase, bone morphogenetic protein 1 (BMP1), a...