Individualized functional connectome identified generalizable biomarkers for psychiatric symptoms in transdiagnostic patients

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 48; no. 4; pp. 633 - 641
• Main Authors: Li, Meiling, Dahmani, Louisa, Hubbard, Catherine S., Hu, Yongbo, Wang, Meiyun, Wang, Danhong, Liu, Hesheng
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.03.2023; Springer International Publishing
• Subjects: Attention Deficit Disorder with Hyperactivity - drug therapy; Attention deficit hyperactivity disorder; Biomarkers; Brain - diagnostic imaging; Brain mapping; Comorbidity; Connectome - methods; Functional magnetic resonance imaging; Humans; Magnetic Resonance Imaging - methods; Mental disorders; Neural networks; Neuroimaging; Patients; Phenotypes; Psychosis; Psychotic Disorders; Schizophrenia

Substantial clinical heterogeneity and comorbidity inherent amongst mental disorders limit the identification of neuroimaging biomarkers that can reliably track clinical symptoms. Strategies that enable generation of meaningful and replicable neurobiological markers at the individual level will push...