Higher Estradiol and Lower Dehydroepiandrosterone-Sulfate Levels Are Associated with Pulmonary Arterial Hypertension in Men

• Published in: American journal of respiratory and critical care medicine Vol. 193; no. 10; pp. 1168 - 1175
• Main Authors: Ventetuolo, Corey E., Baird, Grayson L., Barr, R. Graham, Bluemke, David A., Fritz, Jason S., Hill, Nicholas S., Klinger, James R., Lima, Joao A. C., Ouyang, Pamela, Palevsky, Harold I., Palmisciano, Amy J., Krishnan, Ipsita, Pinder, Diane, Preston, Ioana R., Roberts, Kari E., Kawut, Steven M.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 15.05.2016
• Subjects: Aged; Case-Control Studies; Dehydroepiandrosterone Sulfate - blood; Estradiol - blood; Humans; Hypertension, Pulmonary - blood; Male; Middle Aged; Original; Risk Factors; DHEA; sex hormones; pulmonary hypertension; estradiol

Recent studies have focused on the role of female sex and estradiol (E2) in pulmonary arterial hypertension (PAH), but it is not known whether sex hormones are risk factors for PAH in men. We performed a case-control study to determine whether hormone levels (E2, dehydroepiandrosterone-sulfate [DHEA...