Transporter TAP1-637G and Immunoproteasome PSMB9-60H Variants Influence the Risk of Developing Vitiligo in the Saudi Population

• Published in: Disease markers Vol. 2014; no. 2014; pp. 1 - 8
• Main Authors: Fatani, Abdulhamid, Rashad, Mona, Jiffri, Essam Hussien, Bogari, Neda, Elhawary, Nasser Attia, Tayeb, Mohammed Taher
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2014; John Wiley & Sons, Inc
• Subjects: Adolescent; Adult; ATP-Binding Cassette Sub-Family B Member 2; ATP-Binding Cassette Transporters - genetics; Carrier proteins; Child; Child, Preschool; Cysteine Endopeptidases - genetics; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Health aspects; Humans; Immunoproteins; Male; Middle Aged; Risk Factors; Saudi Arabia; Vitiligo; Vitiligo - genetics; Young Adult; Saudi Arabia

We evaluated whether TAP1-rs1135216 (p.637D>G) and PSMB9-rs17587 (p.60R>H) were significantly associated with the risk and severity of vitiligo among Saudi patients. One hundred seventy-two subjects were genotyped for the TAP1-rs1135216 and PSMB9-rs17587 variants using endonuclease digestions...