Yeast extract inhibits the proliferation of renal cell carcinoma cells via regulation of iron metabolism
The microbiome has recently attracted research interest in a variety of subjects, including cancer. In the present study, it was determined that reinforced clostridium media (RCM) for microbiome culture, exerts antitumor effects on renal cell carcinoma cells when compared to the microbiome 'X&#...
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| Published in | Molecular medicine reports Vol. 20; no. 4; pp. 3933 - 3941 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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Spandidos Publications
01.10.2019
Spandidos Publications UK Ltd |
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| Abstract | The microbiome has recently attracted research interest in a variety of subjects, including cancer. In the present study, it was determined that reinforced clostridium media (RCM) for microbiome culture, exerts antitumor effects on renal cell carcinoma cells when compared to the microbiome 'X'. The antitumor effects of RCM were investigated for all ingredients of RCM, and the results revealed that yeast extract could be a candidate for the ingredient driving this phenomenon. Further experiments including MTT assay, cell counting, cell death analysis, cell cycle analysis and western blotting were conducted with yeast extract on renal cell carcinoma cells (Caki‑1 and Caki‑2) and normal human proximal tubular cells (HK‑2). As a result, yeast extract exhibited dose‑dependent antitumor effects on Caki‑1 and Caki‑2, but only slight effects on HK‑2. In addition, yeast extract only exhibited slight effects on necrosis, autophagy, or apoptosis of Caki‑1 and Caki‑2. Yeast extract produced cell cycle arrest with an increased G0/G1 fraction and a decreased S fraction, and this was considered to be related to the decreased cyclin D1. Although yeast extract treatment increased anti‑oxidant activities, the antitumor effects of yeast extract were also related to iron metabolism, based on the decreased transferrin receptor and increased ferritin. In addition, decreased GPX4 may be related to iron‑dependent cell death, particularly in Caki‑2. These results revealed that yeast extract may inhibit proliferation of renal cell carcinoma cells by regulating iron metabolism. Since an increased iron requirement is a classic phenomenon of cancer cells, yeast extract may be a candidate for adjuvant treatment of renal cell carcinoma. |
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| AbstractList | The microbiome has recently attracted research interest in a variety of subjects, including cancer. In the present study, it was determined that reinforced clostridium media (RCM) for microbiome culture, exerts antitumor effects on renal cell carcinoma cells when compared to the microbiome ‘X’. The antitumor effects of RCM were investigated for all ingredients of RCM, and the results revealed that yeast extract could be a candidate for the ingredient driving this phenomenon. Further experiments including MTT assay, cell counting, cell death analysis, cell cycle analysis and western blotting were conducted with yeast extract on renal cell carcinoma cells (Caki-1 and Caki-2) and normal human proximal tubular cells (HK-2). As a result, yeast extract exhibited dose-dependent antitumor effects on Caki-1 and Caki-2, but only slight effects on HK-2. In addition, yeast extract only exhibited slight effects on necrosis, autophagy, or apoptosis of Caki-1 and Caki-2. Yeast extract produced cell cycle arrest with an increased G0/G1 fraction and a decreased S fraction, and this was considered to be related to the decreased cyclin D1. Although yeast extract treatment increased anti-oxidant activities, the antitumor effects of yeast extract were also related to iron metabolism, based on the decreased transferrin receptor and increased ferritin. In addition, decreased GPX4 may be related to iron-dependent cell death, particularly in Caki-2. These results revealed that yeast extract may inhibit proliferation of renal cell carcinoma cells by regulating iron metabolism. Since an increased iron requirement is a classic phenomenon of cancer cells, yeast extract may be a candidate for adjuvant treatment of renal cell carcinoma. The microbiome has recently attracted research interest in a variety of subjects, including cancer. In the present study, it was determined that reinforced clostridium media (RCM) for microbiome culture, exerts antitumor effects on renal cell carcinoma cells when compared to the microbiome 'X'. The antitumor effects of RCM were investigated for all ingredients of RCM, and the results revealed that yeast extract could be a candidate for the ingredient driving this phenomenon. Further experiments including MTT assay, cell counting, cell death analysis, cell cycle analysis and western blotting were conducted with yeast extract on renal cell carcinoma cells (Caki-1 and Caki-2) and normal human proximal tubular cells (HK-2). As a result, yeast extract exhibited dose-dependent antitumor effects on Caki-1 and Caki-2, but only slight effects on HK-2. In addition, yeast extract only exhibited slight effects on necrosis, autophagy, or apoptosis of Caki-1 and Caki-2. Yeast extract produced cell cycle arrest with an increased [G.sub.0]/[G.sub.1] fraction and a decreased S fraction, and this was considered to be related to the decreased cyclin D1. Although yeast extract treatment increased anti-oxidant activities, the antitumor effects of yeast extract were also related to iron metabolism, based on the decreased transferrin receptor and increased ferritin. In addition, decreased GPX4 may be related to iron-dependent cell death, particularly in Caki-2. These results revealed that yeast extract may inhibit proliferation of renal cell carcinoma cells by regulating iron metabolism. Since an increased iron requirement is a classic phenomenon of cancer cells, yeast extract may be a candidate for adjuvant treatment of renal cell carcinoma. Key words: yeast extract, renal cell carcinoma, iron, cell cycle, ferroptosis The microbiome has recently attracted research interest in a variety of subjects, including cancer. In the present study, it was determined that reinforced clostridium media (RCM) for microbiome culture, exerts antitumor effects on renal cell carcinoma cells when compared to the microbiome 'X'. The antitumor effects of RCM were investigated for all ingredients of RCM, and the results revealed that yeast extract could be a candidate for the ingredient driving this phenomenon. Further experiments including MTT assay, cell counting, cell death analysis, cell cycle analysis and western blotting were conducted with yeast extract on renal cell carcinoma cells (Caki‑1 and Caki‑2) and normal human proximal tubular cells (HK‑2). As a result, yeast extract exhibited dose‑dependent antitumor effects on Caki‑1 and Caki‑2, but only slight effects on HK‑2. In addition, yeast extract only exhibited slight effects on necrosis, autophagy, or apoptosis of Caki‑1 and Caki‑2. Yeast extract produced cell cycle arrest with an increased G0/G1 fraction and a decreased S fraction, and this was considered to be related to the decreased cyclin D1. Although yeast extract treatment increased anti‑oxidant activities, the antitumor effects of yeast extract were also related to iron metabolism, based on the decreased transferrin receptor and increased ferritin. In addition, decreased GPX4 may be related to iron‑dependent cell death, particularly in Caki‑2. These results revealed that yeast extract may inhibit proliferation of renal cell carcinoma cells by regulating iron metabolism. Since an increased iron requirement is a classic phenomenon of cancer cells, yeast extract may be a candidate for adjuvant treatment of renal cell carcinoma.The microbiome has recently attracted research interest in a variety of subjects, including cancer. In the present study, it was determined that reinforced clostridium media (RCM) for microbiome culture, exerts antitumor effects on renal cell carcinoma cells when compared to the microbiome 'X'. The antitumor effects of RCM were investigated for all ingredients of RCM, and the results revealed that yeast extract could be a candidate for the ingredient driving this phenomenon. Further experiments including MTT assay, cell counting, cell death analysis, cell cycle analysis and western blotting were conducted with yeast extract on renal cell carcinoma cells (Caki‑1 and Caki‑2) and normal human proximal tubular cells (HK‑2). As a result, yeast extract exhibited dose‑dependent antitumor effects on Caki‑1 and Caki‑2, but only slight effects on HK‑2. In addition, yeast extract only exhibited slight effects on necrosis, autophagy, or apoptosis of Caki‑1 and Caki‑2. Yeast extract produced cell cycle arrest with an increased G0/G1 fraction and a decreased S fraction, and this was considered to be related to the decreased cyclin D1. Although yeast extract treatment increased anti‑oxidant activities, the antitumor effects of yeast extract were also related to iron metabolism, based on the decreased transferrin receptor and increased ferritin. In addition, decreased GPX4 may be related to iron‑dependent cell death, particularly in Caki‑2. These results revealed that yeast extract may inhibit proliferation of renal cell carcinoma cells by regulating iron metabolism. Since an increased iron requirement is a classic phenomenon of cancer cells, yeast extract may be a candidate for adjuvant treatment of renal cell carcinoma. The microbiome has recently attracted research interest in a variety of subjects, including cancer. In the present study, it was determined that reinforced clostridium media (RCM) for microbiome culture, exerts antitumor effects on renal cell carcinoma cells when compared to the microbiome 'X'. The antitumor effects of RCM were investigated for all ingredients of RCM, and the results revealed that yeast extract could be a candidate for the ingredient driving this phenomenon. Further experiments including MTT assay, cell counting, cell death analysis, cell cycle analysis and western blotting were conducted with yeast extract on renal cell carcinoma cells (Caki-1 and Caki-2) and normal human proximal tubular cells (HK-2). As a result, yeast extract exhibited dose-dependent antitumor effects on Caki-1 and Caki-2, but only slight effects on HK-2. In addition, yeast extract only exhibited slight effects on necrosis, autophagy, or apoptosis of Caki-1 and Caki-2. Yeast extract produced cell cycle arrest with an increased [G.sub.0]/[G.sub.1] fraction and a decreased S fraction, and this was considered to be related to the decreased cyclin D1. Although yeast extract treatment increased anti-oxidant activities, the antitumor effects of yeast extract were also related to iron metabolism, based on the decreased transferrin receptor and increased ferritin. In addition, decreased GPX4 may be related to iron-dependent cell death, particularly in Caki-2. These results revealed that yeast extract may inhibit proliferation of renal cell carcinoma cells by regulating iron metabolism. Since an increased iron requirement is a classic phenomenon of cancer cells, yeast extract may be a candidate for adjuvant treatment of renal cell carcinoma. The microbiome has recently attracted research interest in a variety of subjects, including cancer. In the present study, it was determined that reinforced clostridium media (RCM) for microbiome culture, exerts antitumor effects on renal cell carcinoma cells when compared to the microbiome 'X'. The antitumor effects of RCM were investigated for all ingredients of RCM, and the results revealed that yeast extract could be a candidate for the ingredient driving this phenomenon. Further experiments including MTT assay, cell counting, cell death analysis, cell cycle analysis and western blotting were conducted with yeast extract on renal cell carcinoma cells (Caki‑1 and Caki‑2) and normal human proximal tubular cells (HK‑2). As a result, yeast extract exhibited dose‑dependent antitumor effects on Caki‑1 and Caki‑2, but only slight effects on HK‑2. In addition, yeast extract only exhibited slight effects on necrosis, autophagy, or apoptosis of Caki‑1 and Caki‑2. Yeast extract produced cell cycle arrest with an increased G0/G1 fraction and a decreased S fraction, and this was considered to be related to the decreased cyclin D1. Although yeast extract treatment increased anti‑oxidant activities, the antitumor effects of yeast extract were also related to iron metabolism, based on the decreased transferrin receptor and increased ferritin. In addition, decreased GPX4 may be related to iron‑dependent cell death, particularly in Caki‑2. These results revealed that yeast extract may inhibit proliferation of renal cell carcinoma cells by regulating iron metabolism. Since an increased iron requirement is a classic phenomenon of cancer cells, yeast extract may be a candidate for adjuvant treatment of renal cell carcinoma. |
| Audience | Academic |
| Author | Moon, Daeun Yoon, Sang‑Pil Kim, Jinu |
| Author_xml | – sequence: 1 givenname: Daeun surname: Moon fullname: Moon, Daeun organization: Department of Anatomy, School of Medicine, Jeju National University, Jeju 63243, Republic of Korea – sequence: 2 givenname: Jinu surname: Kim fullname: Kim, Jinu organization: Department of Anatomy, School of Medicine, Jeju National University, Jeju 63243, Republic of Korea – sequence: 3 givenname: Sang‑Pil surname: Yoon fullname: Yoon, Sang‑Pil organization: Department of Anatomy, School of Medicine, Jeju National University, Jeju 63243, Republic of Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31432187$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3389_fonc_2023_1222098 crossref_primary_10_3389_fmolb_2021_763697 crossref_primary_10_1186_s12885_021_08559_0 crossref_primary_10_3389_fimmu_2023_1188520 crossref_primary_10_3389_fonc_2022_931383 crossref_primary_10_3389_fonc_2020_00788 |
| Cites_doi | 10.1159/000475037 10.3390/ijms18081718 10.1053/j.ajkd.2015.09.027 10.3390/ijms18102195 10.2147/DDDT.S150825 10.3892/mmr.2017.6566 10.1111/jcmm.13008 10.1186/s12943-016-0565-8 10.1016/j.nefro.2017.04.004 10.1016/j.cell.2013.12.010 10.1016/j.bbagen.2017.05.019 10.1038/ncb3064 10.1016/j.bcp.2005.11.009 10.1586/era.13.52 10.1089/15230860152409013 10.1159/000332967 10.1016/j.mehy.2016.07.015 10.1158/0008-5472.CAN-10-3614 10.1002/jso.2930100104 10.1007/s10534-017-0037-7 10.1097/CCO.0b013e3282f9782b 10.3389/fonc.2018.00549 10.1016/0090-4295(95)80007-7 10.1016/j.trsl.2016.07.021 10.1007/s10565-017-9399-4 10.1681/ASN.2013080905 10.1159/000473580 10.1016/j.cmet.2012.10.001 |
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| References | Okada (key20200713233918_b12-mmr-20-04-3933) 1970; 19 Martin-Sanchez (key20200713233918_b21-mmr-20-04-3933) 2018; 38 Yoon (key20200713233918_b10-mmr-20-04-3933) 2018; 34 Yu (key20200713233918_b25-mmr-20-04-3933) 1991; 19 Pope (key20200713233918_b5-mmr-20-04-3933) 2017; 179 Pfeifhofer-Obermair (key20200713233918_b23-mmr-20-04-3933) 2018; 8 Friedmann Angeli (key20200713233918_b18-mmr-20-04-3933) 2014; 16 Kim (key20200713233918_b11-mmr-20-04-3933) 2017; 16 Rini (key20200713233918_b3-mmr-20-04-3933) 2008; 20 Yang (key20200713233918_b17-mmr-20-04-3933) 2014; 156 Chui (key20200713233918_b9-mmr-20-04-3933) 2004; 14 Kazan (key20200713233918_b19-mmr-20-04-3933) 2017; 30 Santoni (key20200713233918_b30-mmr-20-04-3933) 2013; 13 Ramezani (key20200713233918_b7-mmr-20-04-3933) 2016; 67 Partin (key20200713233918_b26-mmr-20-04-3933) 1995; 45 Poydock (key20200713233918_b14-mmr-20-04-3933) 1978; 46 Kim (key20200713233918_b16-mmr-20-04-3933) 2001; 3 Latunde-Dada (key20200713233918_b29-mmr-20-04-3933) 2017; 1861 Fanzani (key20200713233918_b22-mmr-20-04-3933) 2017; 18 Torti (key20200713233918_b28-mmr-20-04-3933) 2011; 71 Heffeter (key20200713233918_b15-mmr-20-04-3933) 2006; 71 Bayeva (key20200713233918_b31-mmr-20-04-3933) 2012; 16 Golčić (key20200713233918_b24-mmr-20-04-3933) 2016; 94 Fardon (key20200713233918_b13-mmr-20-04-3933) 1978; 10 Ramezani (key20200713233918_b6-mmr-20-04-3933) 2014; 25 Inamura (key20200713233918_b1-mmr-20-04-3933) 2017; 18 Yu (key20200713233918_b20-mmr-20-04-3933) 2017; 21 Koo (key20200713233918_b2-mmr-20-04-3933) 2015; 13 Compare (key20200713233918_b4-mmr-20-04-3933) 2011; 29 Li (key20200713233918_b8-mmr-20-04-3933) 2017; 11 Brodaczewska (key20200713233918_b32-mmr-20-04-3933) 2016; 15 Kirkali (key20200713233918_b27-mmr-20-04-3933) 1995; 28 |
| References_xml | – volume: 28 start-page: 131 year: 1995 ident: key20200713233918_b27-mmr-20-04-3933 article-title: Ferritin: A tumor marker expressed by renal cell carcinoma publication-title: Eur Urol doi: 10.1159/000475037 – volume: 18 start-page: E1718 issue: pii year: 2017 ident: key20200713233918_b22-mmr-20-04-3933 article-title: Iron, oxidative damage and ferroptosis in rhabdomyosarcoma publication-title: Int J Mol Sci doi: 10.3390/ijms18081718 – volume: 13 start-page: 51 year: 2015 ident: key20200713233918_b2-mmr-20-04-3933 article-title: Epidemiology and treatment patterns of urologic cancers in Korea publication-title: Korean J Urol Oncol – volume: 14 start-page: 925 year: 2004 ident: key20200713233918_b9-mmr-20-04-3933 article-title: Growth inhibitory potential of effective microorganism fermentation extract (EM-X) on cancer cells publication-title: Int J Mol Med – volume: 67 start-page: 483 year: 2016 ident: key20200713233918_b7-mmr-20-04-3933 article-title: Role of the gut microbiome in uremia: A Potential therapeutic target publication-title: Am J Kidney Dis doi: 10.1053/j.ajkd.2015.09.027 – volume: 18 start-page: E2195 issue: pii year: 2017 ident: key20200713233918_b1-mmr-20-04-3933 article-title: Renal cell tumors: Understanding their molecular pathological epidemiology and the 2016 WHO classification publication-title: Int J Mol Sci doi: 10.3390/ijms18102195 – volume: 11 start-page: 3531 year: 2017 ident: key20200713233918_b8-mmr-20-04-3933 article-title: Gut microbiota-derived short-chain fatty acids and kidney diseases publication-title: Drug Des Devel Ther doi: 10.2147/DDDT.S150825 – volume: 16 start-page: 453 year: 2017 ident: key20200713233918_b11-mmr-20-04-3933 article-title: Dexamethasone reduces side population fraction through downregulation of ABCG2 transporter in MCF-7 breast cancer cells publication-title: Mol Med Rep doi: 10.3892/mmr.2017.6566 – volume: 21 start-page: 648 year: 2017 ident: key20200713233918_b20-mmr-20-04-3933 article-title: Ferroptosis, a new form of cell death, and its relationships with tumourous diseases publication-title: J Cell Mol Med doi: 10.1111/jcmm.13008 – volume: 15 start-page: 83 year: 2016 ident: key20200713233918_b32-mmr-20-04-3933 article-title: Choosing the right cell line for renal cell cancer research publication-title: Mol Cancer doi: 10.1186/s12943-016-0565-8 – volume: 38 start-page: 125 year: 2018 ident: key20200713233918_b21-mmr-20-04-3933 article-title: Targeting of regulated necrosis in kidney disease publication-title: Nefrologia doi: 10.1016/j.nefro.2017.04.004 – volume: 156 start-page: 317 year: 2014 ident: key20200713233918_b17-mmr-20-04-3933 article-title: Regulation of ferroptotic cancer cell death by GPX4 publication-title: Cell doi: 10.1016/j.cell.2013.12.010 – volume: 1861 start-page: 1893 year: 2017 ident: key20200713233918_b29-mmr-20-04-3933 article-title: Ferroptosis: Role of lipid peroxidation, iron and ferritinophagy publication-title: Biochim Biophys Acta Gen Subj doi: 10.1016/j.bbagen.2017.05.019 – volume: 46 start-page: 231 year: 1978 ident: key20200713233918_b14-mmr-20-04-3933 article-title: Selective effect of fractions of a yeast extract (PCO) on normal and malignant cells publication-title: Exp Cell Biol – volume: 19 start-page: 99 year: 1970 ident: key20200713233918_b12-mmr-20-04-3933 article-title: The interaction of malignant cells with yeast. II. A new yeast extract inhibiting the growth of malignant cell publication-title: Hiroshima J Med Sci – volume: 16 start-page: 1180 year: 2014 ident: key20200713233918_b18-mmr-20-04-3933 article-title: Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice publication-title: Nat Cell Biol doi: 10.1038/ncb3064 – volume: 71 start-page: 426 year: 2006 ident: key20200713233918_b15-mmr-20-04-3933 article-title: Anticancer activity of the lanthanum compound [tris(1,10-phenanthroline)lanthanum(III)]trithiocyanate (KP772; FFC24) publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2005.11.009 – volume: 13 start-page: 697 year: 2013 ident: key20200713233918_b30-mmr-20-04-3933 article-title: Management of metastatic renal cell carcinoma patients with poor-risk features: Current status and future perspectives publication-title: Expert Rev Anticancer Ther doi: 10.1586/era.13.52 – volume: 3 start-page: 361 year: 2001 ident: key20200713233918_b16-mmr-20-04-3933 article-title: Potential mechanisms for the inhibition of tumor cell growth by manganese superoxide dismutase publication-title: Antioxid Redox Signal doi: 10.1089/15230860152409013 – volume: 29 start-page: 554 year: 2011 ident: key20200713233918_b4-mmr-20-04-3933 article-title: Contribution of gut microbiota to colonic and extracolonic cancer development publication-title: Dig Dis doi: 10.1159/000332967 – volume: 94 start-page: 148 year: 2016 ident: key20200713233918_b24-mmr-20-04-3933 article-title: Changes in metabolic profile, iron and ferritin levels during the treatment of metastatic renal cancer-A new potential biomarker? publication-title: Med Hypotheses doi: 10.1016/j.mehy.2016.07.015 – volume: 71 start-page: 1511 year: 2011 ident: key20200713233918_b28-mmr-20-04-3933 article-title: Ironing out cancer publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-10-3614 – volume: 10 start-page: 10 year: 1978 ident: key20200713233918_b13-mmr-20-04-3933 article-title: Response of neoplastic and non-neoplastic cells to a yeast extract publication-title: J Surg Oncol doi: 10.1002/jso.2930100104 – volume: 30 start-page: 629 year: 2017 ident: key20200713233918_b19-mmr-20-04-3933 article-title: Iron metabolism and drug resistance in cancer publication-title: Biometals doi: 10.1007/s10534-017-0037-7 – volume: 20 start-page: 300 year: 2008 ident: key20200713233918_b3-mmr-20-04-3933 article-title: Renal cell carcinoma publication-title: Curr Opin Oncol doi: 10.1097/CCO.0b013e3282f9782b – volume: 8 start-page: 549 year: 2018 ident: key20200713233918_b23-mmr-20-04-3933 article-title: Iron in the tumor microenvironment-connecting the dots publication-title: Front Oncol doi: 10.3389/fonc.2018.00549 – volume: 45 start-page: 211 year: 1995 ident: key20200713233918_b26-mmr-20-04-3933 article-title: Serum ferritin as a clinical marker for renal cell carcinoma: Influence of tumor volume publication-title: Urology doi: 10.1016/0090-4295(95)80007-7 – volume: 179 start-page: 139 year: 2017 ident: key20200713233918_b5-mmr-20-04-3933 article-title: Microbiota as a mediator of cancer progression and therapy publication-title: Transl Res doi: 10.1016/j.trsl.2016.07.021 – volume: 34 start-page: 251 year: 2018 ident: key20200713233918_b10-mmr-20-04-3933 article-title: Exogenous CGRP upregulates profibrogenic growth factors through PKC/JNK signaling pathway in kidney proximal tubular cells publication-title: Cell Biol Toxicol doi: 10.1007/s10565-017-9399-4 – volume: 25 start-page: 657 year: 2014 ident: key20200713233918_b6-mmr-20-04-3933 article-title: The gut microbiome, kidney disease, and targeted interventions publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2013080905 – volume: 19 start-page: 54 year: 1991 ident: key20200713233918_b25-mmr-20-04-3933 article-title: Serum iron as a tumor marker in renal cell carcinoma publication-title: Eur Urol doi: 10.1159/000473580 – volume: 16 start-page: 645 year: 2012 ident: key20200713233918_b31-mmr-20-04-3933 article-title: mTOR regulates cellular iron homeostasis through tristetraprolin publication-title: Cell Metab doi: 10.1016/j.cmet.2012.10.001 |
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| SubjectTerms | Adjuvant treatment Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Apoptosis Autophagy Cancer Carcinoma, Renal cell Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - microbiology Carcinoma, Renal Cell - therapy Cell culture Cell cycle Cell Cycle Checkpoints - drug effects Cell death Cell Line Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chemotherapy Comparative analysis Culture Media - chemistry Culture Media - pharmacology Cyclin D1 Fatty acids Ferritin Ferroptosis Flow cytometry Gastrointestinal Microbiome Homeostasis Humans Ingredients Instrument industry Iron Iron - metabolism Kidney cancer Kidney diseases Kidney Neoplasms - metabolism Kidney Neoplasms - microbiology Kidney Neoplasms - therapy Kinases Metastasis Microbiomes Microbiota Phagocytosis Pharmaceutical industry Renal cell carcinoma Transferrins Western blotting Yeast Yeasts - chemistry Yeasts - physiology |
| Title | Yeast extract inhibits the proliferation of renal cell carcinoma cells via regulation of iron metabolism |
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