Polydeoxyribonucleotides Improve Diabetic Wound Healing in Mouse Animal Model for Experimental Validation
Wound healing mechanisms is believed to have effects similar to wound healing disorders in diabetic patients, including abnormal inflammatory cells, angiogenesis disorders, and reduced collagen synthesis. Therefore, reestablishment of structural and promoted angiogenesis could be beneficial to promo...
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| Published in | Annals of dermatology Vol. 31; no. 4; pp. 403 - 413 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
The Korean Dermatological Association; The Korean Society for Investigative Dermatology
01.08.2019
대한피부과학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1013-9087 2005-3894 2005-3894 |
| DOI | 10.5021/ad.2019.31.4.403 |
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| Abstract | Wound healing mechanisms is believed to have effects similar to wound healing disorders in diabetic patients, including abnormal inflammatory cells, angiogenesis disorders, and reduced collagen synthesis. Therefore, reestablishment of structural and promoted angiogenesis could be beneficial to promote wound healing process.
Therefore, we investigated whether the polydeoxyribonucleotide (PDRN) that was self-production in Korea, could be useful as an intradermal injection for promoting wound healing. Also, we validate for wound healing effect of PDRN using healing-impaired (db/db) mice.
In this study, we confirmed the effects of PDRN by creating wound models in
and
model. Using an
wound healing assay, we observed that PDRN stimulated closure of wounded monolayers of human fibroblast cells. PDRN (8.25 mg/ml) or phosphate-buffered saline (0.9% NaCl) was injected once daily into the dermis adjacent to the wound for 12 days after skin injury.
Time course observations revealed that mice treated with PDRN showed accelerated wound closure and epidermal and dermal regeneration, enhanced angiogenesis. The wound area and depth decreased at 3, 6, 9, and 12 days after skin injury. Histological evaluation showed an increase of vascular endothelial growth factor, CD31, and collagen fibers in the PDRN group compared with the control group, indicating that PDRN was effective in the treatment of delayed wound healing caused by diabetes.
This study suggests that our PDRN has a wound healing effect in transgenic animal models with cells and diabetes through angiogenesis. |
|---|---|
| AbstractList | Wound healing mechanisms is believed to have effects similar to wound healing disorders in diabetic patients, including abnormal inflammatory cells, angiogenesis disorders, and reduced collagen synthesis. Therefore, reestablishment of structural and promoted angiogenesis could be beneficial to promote wound healing process.
Therefore, we investigated whether the polydeoxyribonucleotide (PDRN) that was self-production in Korea, could be useful as an intradermal injection for promoting wound healing. Also, we validate for wound healing effect of PDRN using healing-impaired (db/db) mice.
In this study, we confirmed the effects of PDRN by creating wound models in
and
model. Using an
wound healing assay, we observed that PDRN stimulated closure of wounded monolayers of human fibroblast cells. PDRN (8.25 mg/ml) or phosphate-buffered saline (0.9% NaCl) was injected once daily into the dermis adjacent to the wound for 12 days after skin injury.
Time course observations revealed that mice treated with PDRN showed accelerated wound closure and epidermal and dermal regeneration, enhanced angiogenesis. The wound area and depth decreased at 3, 6, 9, and 12 days after skin injury. Histological evaluation showed an increase of vascular endothelial growth factor, CD31, and collagen fibers in the PDRN group compared with the control group, indicating that PDRN was effective in the treatment of delayed wound healing caused by diabetes.
This study suggests that our PDRN has a wound healing effect in transgenic animal models with cells and diabetes through angiogenesis. Background: Wound healing mechanisms is believed to have effects similar to wound healing disorders in diabetic patients, including abnormal inflammatory cells, angiogenesis disorders, and reduced collagen synthesis. Therefore, reestablishment of structural and promoted angiogenesis could be beneficial to promote wound healing process. Objective: Therefore, we investigated whether the polydeoxyribonucleotide (PDRN) that was self-production in Korea, could be useful as an intradermal injection for promoting wound healing. Also, we validate for wound healing effect of PDRN using healing-impaired (db/db) mice. Methods: In this study, we confirmed the effects of PDRN by creating wound models in in vitro and in vivo model. Using an in vitro wound healing assay, we observed that PDRN stimulated closure of wounded monolayers of human fibroblast cells. PDRN (8.25 mg/ml) or phosphate-buffered saline (0.9% NaCl) was injected once daily into the dermis adjacent to the wound for 12 days after skin injury. Results: Time course observations revealed that mice treated with PDRN showed accelerated wound closure and epidermal and dermal regeneration, enhanced angiogenesis. The wound area and depth decreased at 3, 6, 9, and 12 days after skin injury. Histological evaluation showed an increase of vascular endothelial growth factor, CD31, and collagen fibers in the PDRN group compared with the control group, indicating that PDRN was effective in the treatment of delayed wound healing caused by diabetes. Conclusion: This study suggests that our PDRN has a wound healing effect in transgenic animal models with cells and diabetes through angiogenesis. KCI Citation Count: 1 Wound healing mechanisms is believed to have effects similar to wound healing disorders in diabetic patients, including abnormal inflammatory cells, angiogenesis disorders, and reduced collagen synthesis. Therefore, reestablishment of structural and promoted angiogenesis could be beneficial to promote wound healing process.BACKGROUNDWound healing mechanisms is believed to have effects similar to wound healing disorders in diabetic patients, including abnormal inflammatory cells, angiogenesis disorders, and reduced collagen synthesis. Therefore, reestablishment of structural and promoted angiogenesis could be beneficial to promote wound healing process.Therefore, we investigated whether the polydeoxyribonucleotide (PDRN) that was self-production in Korea, could be useful as an intradermal injection for promoting wound healing. Also, we validate for wound healing effect of PDRN using healing-impaired (db/db) mice.OBJECTIVETherefore, we investigated whether the polydeoxyribonucleotide (PDRN) that was self-production in Korea, could be useful as an intradermal injection for promoting wound healing. Also, we validate for wound healing effect of PDRN using healing-impaired (db/db) mice.In this study, we confirmed the effects of PDRN by creating wound models in in vitro and in vivo model. Using an in vitro wound healing assay, we observed that PDRN stimulated closure of wounded monolayers of human fibroblast cells. PDRN (8.25 mg/ml) or phosphate-buffered saline (0.9% NaCl) was injected once daily into the dermis adjacent to the wound for 12 days after skin injury.METHODSIn this study, we confirmed the effects of PDRN by creating wound models in in vitro and in vivo model. Using an in vitro wound healing assay, we observed that PDRN stimulated closure of wounded monolayers of human fibroblast cells. PDRN (8.25 mg/ml) or phosphate-buffered saline (0.9% NaCl) was injected once daily into the dermis adjacent to the wound for 12 days after skin injury.Time course observations revealed that mice treated with PDRN showed accelerated wound closure and epidermal and dermal regeneration, enhanced angiogenesis. The wound area and depth decreased at 3, 6, 9, and 12 days after skin injury. Histological evaluation showed an increase of vascular endothelial growth factor, CD31, and collagen fibers in the PDRN group compared with the control group, indicating that PDRN was effective in the treatment of delayed wound healing caused by diabetes.RESULTSTime course observations revealed that mice treated with PDRN showed accelerated wound closure and epidermal and dermal regeneration, enhanced angiogenesis. The wound area and depth decreased at 3, 6, 9, and 12 days after skin injury. Histological evaluation showed an increase of vascular endothelial growth factor, CD31, and collagen fibers in the PDRN group compared with the control group, indicating that PDRN was effective in the treatment of delayed wound healing caused by diabetes.This study suggests that our PDRN has a wound healing effect in transgenic animal models with cells and diabetes through angiogenesis.CONCLUSIONThis study suggests that our PDRN has a wound healing effect in transgenic animal models with cells and diabetes through angiogenesis. |
| Author | Kim, Jong Hwan Kim, Jae Min Hong, Ji Yeon Han, Sung Won Lee, Byung Chul Kwon, Tae-Rin Kim, Beom Joon |
| AuthorAffiliation | 2 Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea 1 Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea |
| AuthorAffiliation_xml | – name: 1 Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea – name: 2 Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea |
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| Cites_doi | 10.1016/S0002-9440(10)61151-0 10.3389/fphar.2017.00224 10.1046/j.1365-2133.2003.05164.x 10.1016/j.jvs.2011.07.083 10.1111/j.1524-475X.2008.00361.x 10.1007/s12325-017-0478-y 10.2337/diacare.22.1.157 10.1186/s40902-016-0053-5 10.1046/j.1524-475X.1999.00335.x 10.1161/ATVBAHA.108.178962 10.1016/j.canlet.2003.11.008 10.1172/JCI32169 10.1111/j.1524-475X.2008.00410.x 10.3390/ijms18081698 10.1016/j.jvs.2010.07.044 10.1038/jid.2012.228 10.1371/journal.pone.0036974 10.2353/ajpath.2006.051314 10.2119/2006-00054.Brem 10.1111/aos.12806 10.1016/j.lfs.2017.02.015 10.2174/187152509789541909 10.1002/jcp.25663 10.1016/j.surg.2010.04.024 10.1097/CCM.0b013e318170ab5c 10.1038/jid.2011.176 |
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| Keywords | CD31 Diabetes mouse model Wound healing Vascular endothelial growth factor A Polyribonucleotide |
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| Title | Polydeoxyribonucleotides Improve Diabetic Wound Healing in Mouse Animal Model for Experimental Validation |
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