Newly divided eosinophils limit ozone-induced airway hyperreactivity in nonsensitized guinea pigs

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 312; no. 6; pp. L969 - L982
• Main Authors: Wicher, Sarah A., Jacoby, David B., Fryer, Allison D.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.06.2017
• Subjects: Alveoli; Animals; Antibodies; Atopy; Bone marrow; Bradycardia - complications; Bradycardia - immunology; Bradycardia - pathology; Bradycardia - physiopathology; Bromodeoxyuridine - metabolism; Bronchial Hyperreactivity - blood; Bronchial Hyperreactivity - chemically induced; Bronchial Hyperreactivity - immunology; Bronchial Hyperreactivity - physiopathology; Bronchoalveolar Lavage Fluid - immunology; Bronchoconstriction; Bronchoconstriction - drug effects; Bronchus; Cell Division - drug effects; Cells; Depletion; Electric Stimulation; Eosinophils; Eosinophils - drug effects; Eosinophils - pathology; Etanercept - pharmacology; Female; Guinea Pigs; Hematopoiesis; Hypersensitivity; Immunization; Inflammation; Inflammatory response; Interleukin 5; Leukocytes; Leukocytes (eosinophilic); Lungs; Lymphocytes - drug effects; Lymphocytes - pathology; Macrophages - drug effects; Macrophages - metabolism; Methacholine Chloride - pharmacology; Monocytes - drug effects; Monocytes - pathology; Neutrophils - drug effects; Neutrophils - pathology; Ozone; Recruitment; Respiratory system; Respiratory tract; Swine; Tumor necrosis factor-α; Vagus Nerve - drug effects; Vagus Nerve - physiopathology; airway hyperreactivity; eosinophil hematopoiesis; sensitization; ozone; 5-bromo-2-deoxyuridine

Ozone causes vagally mediated airway hyperreactivity and recruits inflammatory cells, including eosinophils, to lungs, where they mediate ozone-induced hyperreactivity 1 day after exposure but are paradoxically protective 3 days later. We aimed to test the role of newly divided eosinophils in ozone-...