Neuroprotective effects of p53/microRNA‑22 regulate inflammation and apoptosis in subarachnoid hemorrhage

• Published in: International journal of molecular medicine Vol. 41; no. 4; pp. 2406 - 2412
• Main Authors: Yu, Shui, Zeng, Yi-Jun, Sun, Xiao-Chuan
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.04.2018; Spandidos Publications UK Ltd
• Subjects: Apoptosis; Care and treatment; Cytokines; Development and progression; Gene expression; Genetic aspects; Health aspects; Hemorrhage; Inflammation; Kinases; Medical prognosis; MicroRNA; MicroRNAs; Mortality; Pathogenesis; Protein expression; Proteins; RNA polymerase; Rodents; Subarachnoid hemorrhage; China

The present study aimed to investigate whether the neuroprotective effects of p53/microRNA‑22 regulate inflammation and apoptosis in subarachnoid hemorrhage (SAH). In a mouse model of SAH, microRNA‑22 expression was upregulated. In addition, downregulation of microRNA‑22 in HEB cells increased the m...