Regulator of G protein signalling 18 promotes osteocyte proliferation by activating the extracellular signal‑regulated kinase signalling pathway

• Published in: International journal of molecular medicine Vol. 53; no. 3; p. 1
• Main Authors: Meng, Yong, Qiu, Si-Qiang, Wang, Qiang, Zuo, Jin-Liang
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.03.2024; Spandidos Publications UK Ltd
• Subjects: Analysis; Apoptosis; Bioinformatics; Biotechnology; Cell cycle; Flow cytometry; Fractures; G proteins; Gene expression; Genes; Joint and ligament injuries; Kinases; Life sciences; Penicillin; Proteins; Scientific equipment and supplies industry; United States; osteocytes; extracellular signal‑regulated kinase signalling; proliferation; regulator of G protein signalling 18; bone fracture

Osteocyte function is critical for metabolism, remodelling and regeneration of bone tissue. In the present study, the roles of regulator of G protein signalling 18 (RGS18) were assessed in the regulation of osteocyte proliferation and bone formation. Target genes and signalling pathways were screene...