A distributed frontotemporal network underlies gamma-band synchronization impairments in schizophrenia patients

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 45; no. 13; pp. 2198 - 2206
• Main Authors: Koshiyama, Daisuke, Miyakoshi, Makoto, Joshi, Yash B., Molina, Juan L., Tanaka-Koshiyama, Kumiko, Sprock, Joyce, Braff, David L., Swerdlow, Neal R., Light, Gregory A.
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.12.2020; Springer International Publishing
• Subjects: Acoustic Stimulation; Auditory Cortex; Cortex (frontal); Drug development; EEG; Electroencephalography; Evoked Potentials, Auditory; Humans; Interneurons; Mental disorders; Oscillations; Parvalbumin; Pyramidal cells; Schizophrenia; Synchronization; Temporal cortex; γ-Aminobutyric acid

Synaptic interactions between parvalbumin-positive γ-aminobutyric acid (GABA)-ergic interneurons and pyramidal neurons evoke cortical gamma oscillations, which are known to be abnormal in schizophrenia. These cortical gamma oscillations can be indexed by the gamma-band auditory steady-state response...