The mammalian carboxylesterases: from molecules to functions

• Published in: Annual review of pharmacology and toxicology Vol. 38; no. 1; pp. 257 - 288
• Main Authors: Satoh, T, Hosokawa, M
• Format: Journal Article
• Language: English
• Published: United States Annual Reviews, Inc 01.01.1998
• Subjects: Animals; Carboxylic Ester Hydrolases - biosynthesis; Carboxylic Ester Hydrolases - chemistry; Carboxylic Ester Hydrolases - metabolism; Carboxylic Ester Hydrolases - physiology; Humans; Pharmaceutical Preparations - metabolism

Multiple carboxylesterases (EC 3.1.1.1) play an important role in the hydrolytic biotransformation of a vast number of structurally diverse drugs. These enzymes are major determinants of the pharmacokinetic behavior of most therapeutic agents containing ester or amide bonds. Carboxylesterase activit...