B-cell depletion abrogates immune mediated cytopenia and rejection of cord blood transplantation in Hurler syndrome

• Published in: Bone marrow transplantation (Basingstoke) Vol. 57; no. 1; pp. 38 - 42
• Main Authors: Nataraj, R, Hiwarkar, P, Bonney, D, Campbell, H, Jones, S, Deambrosis, D, Evans, P, Poulton, K, van Hasselt, P M, Bierings, M B, Boelens, J J, Lindemans, C A, Wynn, R
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.01.2022; Nature Publishing Group UK
• Subjects: Antibodies; Blood; Child; Chimerism; Conditioning; Cord blood; Cord Blood Stem Cell Transplantation - adverse effects; Cytopenia; Depletion; Failure; Graft rejection; Graft vs Host Disease - etiology; Grafting; Grafts; Hematopoietic Stem Cell Transplantation - adverse effects; Humans; Lymphocytes B; Metabolic disorders; Metabolism; Mucopolysaccharidosis I; Patients; Pediatrics; Rituximab; Rituximab - therapeutic use; Stem cell transplantation; Survival; Transplantation; Transplantation Conditioning - adverse effects; Transplants; Transplants & implants; Umbilical cord

Umbilical cord blood is the preferred donor cell source for children with Inherited Metabolic disorders undergoing Hematopoietic Cell Transplant (HCT), and its use has been associated with improved "engrafted survival" and higher donor chimerism compared to other cell sources. However, as...